Mouse Anti-TET2 Recombinant Antibody (CBYJT-2574) (CBMAB-T1744-YJ)

Name: Mouse Anti-TET2 Recombinant Antibody (CBYJT-2574)
SKU: CBMAB-T1744-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJT-2574

Application

WB, IP

Immunogen

The exact sequence is proprietary

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TET2 Gene(Protein Coding) Tet Methylcytosine Dioxygenase 2

Introduction

TET2 is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. TET2 is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders.

Entrez Gene ID

54790

UniProt ID

Q6N021

Alternative Names

Tet Methylcytosine Dioxygenase 2; KIAA1546; Tet Oncogene Family Member 2; EC 1.14.11.n2; Probable Methylcytosine Dioxygenase TET2; Methylcytosine Dioxygenase TET2; MDS

Function

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.

Biological Process

Biological Process 5-methylcytosine catabolic processSource:UniProtKB1 Publication
Biological Process cell cycleSource:UniProtKB-KW
Biological Process chromatin organizationSource:UniProtKB-KW
Biological Process DNA demethylationSource:UniProtKB1 Publication
Biological Process histone H3-K4 trimethylationSource:UniProtKB1 Publication
Biological Process leukocyte differentiationSource:UniProtKB1 Publication
Biological Process myeloid cell differentiationSource:UniProtKB1 Publication
Biological Process oxidative demethylationSource:GO_Central1 Publication
Biological Process oxidative DNA demethylationSource:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase IISource:UniProtKB2 Publications
Biological Process protein O-linked glycosylationSource:UniProtKB1 Publication
Biological Process response to organic cyclic compoundSource:Ensembl

Cellular Location

Nucleus

Involvement in disease

Polycythemia vera (PV):
A myeloproliferative disorder characterized by abnormal proliferation of all hematopoietic bone marrow elements, erythroid hyperplasia, an absolute increase in total blood volume, but also by myeloid leukocytosis, thrombocytosis and splenomegaly.
Myelodysplastic syndrome (MDS):
A heterogeneous group of closely related clonal hematopoietic disorders. All are characterized by a hypercellular or hypocellular bone marrow with impaired morphology and maturation, dysplasia of the myeloid, megakaryocytic and/or erythroid lineages, and peripheral blood cytopenias resulting from ineffective blood cell production. Included diseases are: refractory anemia (RA), refractory anemia with ringed sideroblasts (RARS), refractory anemia with excess blasts (RAEB), refractory cytopenia with multilineage dysplasia and ringed sideroblasts (RCMD-RS); chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative disease. MDS is considered a premalignant condition in a subgroup of patients that often progresses to acute myeloid leukemia (AML).
Immunodeficiency 75 (IMD75):
An autosomal recessive immunologic disorder characterized by recurrent infections, mainly viral and affecting the respiratory tract, immunodeficieny, immune dysregulation, and the development of lymphoproliferative disorders, including lymphoma.

PTM

May be glycosylated. It is unclear whether interaction with OGT leads to GlcNAcylation. According to a report, it is not GlcNAcylated by OGT (PubMed:23353889).
In contrast, another group reports GlcNAcylation by OGT in mouse ortholog.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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