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Rabbit Anti-THOP1 Monoclonal Antibody (EPR7651) (CBMAB-1634-YC)

Provided herein is a rabbit monoclonal antibody against Human THOP1. The antibody, clone EPR7651, can be used for immunoassay techniques, such as ICC, IF and WB.
See all THOP1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR7651
Antibody Isotype
IgG
Application
ICC, IF, WB

Basic Information

Immunogen
Synthetic peptide, corresponding to residues in Human Thimet Oligopeptidase
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
THOP1 Gene(Protein Coding) Thimet Oligopeptidase 1
Introduction
THOP1 is a kininase that uses zinc as a cofactor. THOP1 cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. THOP1 also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides.
Entrez Gene ID
Human7064
Mouse50492
Rat64517
UniProt ID
HumanP52888
MouseQ8C1A5
RatP24155
Alternative Names
thimet oligopeptidase; endopeptidase EC3.4.24.15; EC 3.4.24.15
Function
Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation (PubMed:7639763, PubMed:17251185).
Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (PubMed:7639763, PubMed:17251185).
Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity).
Biological Process
Biological Process peptide metabolic processSource:GO_Central1 Publication
Biological Process protein polyubiquitinationSource:Reactome
Biological Process proteolysisSource:GO_Central1 Publication
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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