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Mouse Anti-TNFAIP6 Recombinant Antibody (CBYJT-3642) (CBMAB-T2999-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TNFAIP6 (TNF Alpha Induced Protein 6). The antibody can be used for immunoassay techniques, such as WB.
See all TNFAIP6 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBYJT-3642
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human TSG-6, Trp18-Leu277, Accession # P98066
Specificity
Human, Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, Trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 18-277

Target

Full Name
TNF Alpha Induced Protein 6
Introduction
TNFAIP6 is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. It has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. TNFAIP6 can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.
Entrez Gene ID
Human7130
Mouse21930
UniProt ID
HumanP98066
MouseO08859
Alternative Names
TNF Alpha Induced Protein 6; TNF-Stimulated Gene 6 Protein; Hyaluronate-Binding Protein; TSG-6; TSG6; Tumor Necrosis Factor Alpha-Inducible Protein 6; Tumor Necrosis Factor-Stimulated Gene-6 Protein
Function
Major regulator of extracellular matrix organization during tissue remodeling (PubMed:18042364, PubMed:26823460, PubMed:15917224).
Catalyzes the transfer of a heavy chain (HC) from inter-alpha-inhibitor (I-alpha-I) complex to hyaluronan. Cleaves the ester bond between the C-terminus of the HC and GalNAc residue of the chondroitin sulfate chain in I-alpha-I complex followed by transesterification of the HC to hyaluronan. In the process, potentiates the antiprotease function of I-alpha-I complex through release of free bikunin (PubMed:20463016, PubMed:15917224, PubMed:16873769).
Acts as a catalyst in the formation of hyaluronan-HC oligomers and hyaluronan-rich matrix surrounding the cumulus cell-oocyte complex, a necessary step for oocyte fertilization (PubMed:26468290).
Assembles hyaluronan in pericellular matrices that serve as platforms for receptor clustering and signaling. Enables binding of hyaluronan deposited on the surface of macrophages to LYVE1 on lymphatic endothelium and facilitates macrophage extravasation. Alters hyaluronan binding to functionally latent CD44 on vascular endothelium, switching CD44 into an active state that supports leukocyte rolling (PubMed:26823460, PubMed:15060082).
Modulates the interaction of chemokines with extracellular matrix components and proteoglycans on endothelial cell surface, likely preventing chemokine gradient formation (PubMed:27044744).
In a negative feedback mechanism, may limit excessive neutrophil recruitment at inflammatory sites by antagonizing the association of CXCL8 with glycosaminoglycans on vascular endothelium (PubMed:24501198).
Has a role in osteogenesis and bone remodeling. Inhibits BMP2-dependent differentiation of mesenchymal stem cell to osteoblasts (PubMed:18586671, PubMed:16771708).
Protects against bone erosion during inflammation by inhibiting TNFSF11/RANKL-dependent osteoclast activation (PubMed:18586671).
Biological Process
Biological Process cell adhesionSource:UniProtKB-KW
Biological Process cell-cell signalingSource:ProtInc1 Publication
Biological Process fibronectin fibril organizationSource:UniProtKB1 Publication
Biological Process hyaluronan metabolic processSource:UniProtKB2 Publications
Biological Process inflammatory responseSource:ProtInc1 Publication
Biological Process negative regulation of BMP signaling pathwaySource:UniProtKB1 Publication
Biological Process negative regulation of inflammatory responseSource:CACAO1 Publication
Biological Process negative regulation of neutrophil chemotaxisSource:UniProtKB1 Publication
Biological Process negative regulation of osteoblast differentiationSource:UniProtKB2 Publications
Biological Process negative regulation of osteoclast differentiationSource:UniProtKB1 Publication
Biological Process ovarian cumulus expansionSource:UniProtKB
Biological Process ovulationSource:Ensembl
Biological Process positive regulation of cell migrationSource:Ensembl
Biological Process positive regulation of receptor clusteringSource:UniProtKB1 Publication
Biological Process signal transductionSource:ProtInc1 Publication
Cellular Location
Secreted
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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