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Rat Anti-TNPO1 Recombinant Antibody (CBYJT-4117) (CBMAB-T3556-YJ)

Provided herein is a Rat monoclonal antibody, which binds to TNPO1 (Transportin 1). The antibody can be used for immunoassay techniques, such as ICC, WB.
See all TNPO1 antibodies

Summary

Host Animal
Rat
Specificity
Human
Clone
CBYJT-4117
Antibody Isotype
IgG2a, κ
Application
ICC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2, 50% Glycerol
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
transportin 1
Introduction
TNPO1 is the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins.
Entrez Gene ID
3842
UniProt ID
Q92973
Alternative Names
Transportin 1; Karyopherin (Importin) Beta 2; M9 Region Interaction Protein; Karyopherin Beta-2; Importin 2; KPNB2; MIP1
Function
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:24753571).
May mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).
Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607).
In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (By similarity).
In vitro, mediates nuclear import of SRP19 (PubMed:11682607).
Mediates nuclear import of ADAR/ADAR1 isoform 1 and isoform 5 in a RanGTP-dependent manner (PubMed:19124606, PubMed:24753571).
(Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.
Biological Process
Protein import into nucleus
Cellular Location
Cytoplasm
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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