Mouse Anti-TPP1 (AA 1-544) Recombinant Antibody (CBFYC-3206) (CBMAB-C3283-FY)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases (PubMed:11054422, PubMed:19038966, PubMed:19038967).
Requires substrates with an unsubstituted N-terminus (PubMed:19038966).
Biological Process central nervous system development Source:GO_Central1 Publication
Biological Process epithelial cell differentiation Source:UniProtKB1 Publication
Biological Process lipid metabolic process Source:ProtInc1 Publication
Biological Process lysosomal protein catabolic process Source:Ensembl
Biological Process lysosome organization Source:UniProtKB
Biological Process nervous system development Source:UniProtKB1 Publication
Biological Process neuromuscular process controlling balance Source:UniProtKB
Biological Process peptide catabolic process Source:UniProtKB2 Publications
Biological Process protein catabolic process Source:UniProtKB1 Publication
Biological Process protein localization to chromosome, telomeric region Source:CACAO1 Publication
Biological Process proteolysis Source:UniProtKB2 Publications
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
A form of neuronal ceroid lipofuscinosis. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. The lipopigment pattern seen most often in CLN2 consists of curvilinear profiles.
Spinocerebellar ataxia, autosomal recessive, 7 (SCAR7):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR7 patients show difficulty walking and writing, dysarthria, limb ataxia, and cerebellar atrophy.
N-glycosylation is required for processing and activity (PubMed:19038966, PubMed:19038967).
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
Antibody Pairs
TPP1 Matched Antibody Pair (1263) (CAT#: APMAB-1263LY)
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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