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Mouse Anti-TPP2 Recombinant Antibody (CBYJT-4386) (CBMAB-T3879-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4386
Antibody Isotype
IgG2b
Application
ELISA, WB, IHC, IF, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TPP2 Tripeptidyl Peptidase 2
Introduction
TPP2 is a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. TPP2 has a specialized function that is essential for some MHC class I antigen presentation. TPP2 is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class.
Entrez Gene ID
7174
UniProt ID
P29144
Alternative Names
Tripeptidyl Peptidase 2; Tripeptidyl Aminopeptidase; Tripeptidyl-Peptidase II; EC 3.4.14.10; TPP-II; TPP-2; Tripeptidyl Peptidase II; Tripeptidyl-Peptidase 2; TPPII
Function
Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (PubMed:25525876, PubMed:30533531).
It plays an important role in intracellular amino acid homeostasis (PubMed:25525876).
Stimulates adipogenesis (By similarity).
Biological Process
Biological Process amino acid homeostasis Source:UniProtKB1 Publication
Biological Process protein polyubiquitination Source:Reactome
Biological Process proteolysis Source:ProtInc1 Publication
Cellular Location
Cytoplasm
Nucleus
Translocates to the nucleus in response to gamma-irradiation.
Involvement in disease
Immunodeficiency 78 with autoimmunity and developmental delay (IMD78):
An autosomal recessive disorder characterized by immune dysregulation, increased susceptibility to bacterial, viral and fungal infections, recurrent sinopulmonary or skin infections, and autoimmune abnormalities including hemolytic anemia and autoimmune cytopenias. Patients also have global developmental delay with speech delay and variable intellectual disability. Disease onset is in infancy or early childhood.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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