Mouse Anti-TPP2 Recombinant Antibody (CBYJT-4386) (CBMAB-T3879-YJ)

Name: Mouse Anti-TPP2 Recombinant Antibody (CBYJT-4386)
SKU: CBMAB-T3879-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-4386

Application

ELISA, WB, IHC, IF, FC

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TPP2 Tripeptidyl Peptidase 2

Introduction

TPP2 is a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. TPP2 has a specialized function that is essential for some MHC class I antigen presentation. TPP2 is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class.

Entrez Gene ID

7174

UniProt ID

P29144

Alternative Names

Tripeptidyl Peptidase 2; Tripeptidyl Aminopeptidase; Tripeptidyl-Peptidase II; EC 3.4.14.10; TPP-II; TPP-2; Tripeptidyl Peptidase II; Tripeptidyl-Peptidase 2; TPPII

Function

Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (PubMed:25525876, PubMed:30533531).
It plays an important role in intracellular amino acid homeostasis (PubMed:25525876).
Stimulates adipogenesis (By similarity).

Biological Process

Biological Process amino acid homeostasis Source:UniProtKB1 Publication
Biological Process protein polyubiquitination Source:Reactome
Biological Process proteolysis Source:ProtInc1 Publication

Cellular Location

Cytoplasm
Nucleus
Translocates to the nucleus in response to gamma-irradiation.

Involvement in disease

Immunodeficiency 78 with autoimmunity and developmental delay (IMD78):
An autosomal recessive disorder characterized by immune dysregulation, increased susceptibility to bacterial, viral and fungal infections, recurrent sinopulmonary or skin infections, and autoimmune abnormalities including hemolytic anemia and autoimmune cytopenias. Patients also have global developmental delay with speech delay and variable intellectual disability. Disease onset is in infancy or early childhood.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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