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Mouse Anti-TRIM29 Recombinant Antibody (CBT4831) (V2LY-0625-LY1035)


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Tested Data
Mouse Anti-TRIM29 Recombinant Antibody (CBT4831) (V2LY-0625-LY1035) in ELISA
Mouse Anti-TRIM29 Recombinant Antibody (CBT4831) (V2LY-0625-LY1035) in ELISA
Mouse Anti-TRIM29 Recombinant Antibody (CBT4831) (V2LY-0625-LY1035) in WB
Mouse Anti-TRIM29 Recombinant Antibody (CBT4831) (V2LY-0625-LY1035) in WB
Mouse Anti-TRIM29 Recombinant Antibody (CBT4831) (V2LY-0625-LY1035) in WB
Mouse Anti-TRIM29 Recombinant Antibody (CBT4831) (V2LY-0625-LY1035) in WB
Mouse Anti-TRIM29 Recombinant Antibody (CBT4831) (V2LY-0625-LY1035) in WB
Mouse Anti-TRIM29 Recombinant Antibody (CBT4831) (V2LY-0625-LY1035) in WB
Mouse Anti-TRIM29 Recombinant Antibody (CBT4831) (V2LY-0625-LY1035) in IF
Mouse Anti-TRIM29 Recombinant Antibody (CBT4831) (V2LY-0625-LY1035) in IF
Mouse Anti-TRIM29 Recombinant Antibody (CBT4831) (V2LY-0625-LY1035) in FC
Mouse Anti-TRIM29 Recombinant Antibody (CBT4831) (V2LY-0625-LY1035) in FC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4831
Antibody Isotype
IgG2a
Application
WB, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human TRIM29 (AA: 451-588) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ICC1:100-1:500
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Tripartite Motif Containing 29
Entrez Gene ID
23650
Function
Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
Biological Process
Biological Process innate immune response Source:UniProtKB-KW
Biological Process negative regulation of protein localization to nucleus Source:Ensembl
Biological Process negative regulation of transcription by RNA polymerase II Source:Ensembl
Cellular Location
Cytoplasm
Lysosome
Colocalizes with intermediate filaments.
PTM
Constitutively phosphorylated by PKC on serine/threonine in A431 cells.
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For research use only. Not intended for any clinical use.

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