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Mouse Anti-TUBG1 Recombinant Antibody (4511) (CBMAB-G6665-LY)

This product is antibody recognizes TUBG1. The antibody 4511 immunoassay techniques such as: WB.
See all TUBG1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
4511
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Recombinant protein encompassing a sequence within the center region of human gamma Tubulin. The exact sequence is proprietary
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TUBG1 Gene(Protein Coding) Tubulin Gamma 1
Introduction
This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7. [provided by RefSeq, Jan 2009]
Entrez Gene ID
Human7283
Mouse103733
Rat252921
UniProt ID
HumanP23258
MouseP83887
RatP83888
Alternative Names
Tubulin Gamma 1; Gamma-Tubulin Complex Component 1; Tubulin; Gamma Polypeptide; GCP-1; TUBG; Tubulin Gamma-1 Chain;
Function
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
Biological Process
Biological Process cytoplasmic microtubule organization Source:InterPro
Biological Process meiotic spindle organization Source:UniProtKB
Biological Process microtubule cytoskeleton organization Source:GO_Central1 Publication
Biological Process microtubule nucleation Source:GO_Central1 Publication
Biological Process mitotic cell cycle Source:GO_Central1 Publication
Biological Process mitotic sister chromatid segregation Source:GO_Central1 Publication
Biological Process mitotic spindle organization Source:GO_Central1 Publication
Cellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, spindle
Localizes to mitotic spindle microtubules.
Involvement in disease
Cortical dysplasia, complex, with other brain malformations 4 (CDCBM4):
A disorder of aberrant neuronal migration and disturbed axonal guidance. Clinical features include early-onset seizures, microcephaly, spastic tetraplegia, and various malformations of cortical development, such as agyria, posterior or frontal pachygyria, thick cortex, and subcortical band heterotopia and thin corpus callosum in some patients.
PTM
Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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