Mouse Anti-XRCC6 Recombinant Antibody (A1440) (CBMAB-AP11247LY)

Name: Mouse Anti-XRCC6 Recombinant Antibody (A1440)
SKU: CBMAB-AP11247LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

A1440

Application

ICC, IP, WB

Immunogen

Purified recombinant human Ku70 protein fragments expressed in Ecoli

Specificity

Human, Monkey

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

X-Ray Repair Cross Complementing 6

Introduction

The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	2547
Monkey	707975

UniProt ID

Human	P12956
Monkey	H9ET71

Function

MB0185

Biological Process

Biological Process activation of innate immune response Source:UniProtKB1 Publication
Biological Process cellular response to gamma radiation Source:UniProtKB1 Publication
Biological Process cellular response to X-ray Source:GO_Central1 Publication
Biological Process DNA ligation Source:ProtInc1 Publication
Biological Process double-strand break repair via classical nonhomologous end joining Source:BHF-UCL1 Publication
Biological Process double-strand break repair via nonhomologous end joining Source:UniProtKB2 Publications
Biological Process innate immune response Source:UniProtKB-KW
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process positive regulation of lymphocyte differentiation Source:UniProtKB
Biological Process positive regulation of protein kinase activity Source:CAFA1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:BHF-UCL1 Publication
Biological Process recombinational repair Source:ComplexPortal1 Publication
Biological Process regulation of smooth muscle cell proliferation Source:UniProtKB1 Publication
Biological Process telomere maintenance Source:GO_Central1 Publication

Cellular Location

Nucleus
Chromosome

PTM

Phosphorylation by PRKDC may enhance helicase activity. Phosphorylation of Ser-51 does not affect DNA repair.
ADP-ribosylated by PARP3.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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