By Research Area

Thrombosis & Hemostasis Research

Creative Biolabs supplies antibodies for coagulation, platelet activation, fibrin formation, and hemostasis pathway studies. Thrombosis and hemostasis antibodies can be explored through cardiovascular disease research categories with product groups for coagulation factor antibodies, platelet activation antibodies, fibrinogen antibody searches, thrombin generation markers, von Willebrand factor antibody selection, and PF4 antibody research.

Platelet Activation and Platelet-Associated Markers

Thrombosis research often begins with platelet adhesion, activation, aggregation, and granule release. Platelet activation antibodies may target CD41/ITGA2B, CD61/ITGB3, CD62P/P-selectin, GP1BA, GP6, PF4/CXCL4, thrombospondin, and other platelet-associated proteins. These targets can support flow cytometry, immunofluorescence, western blotting, and assay-development research.

Research focus Representative antibody targets Common research use
Platelet identity CD41, CD61, GP1BA, GP6 Platelet lineage, adhesion, and receptor studies
Activation and granule release CD62P, PF4/CXCL4, thrombospondin Activation-state and secretion-related assays
Platelet-endothelium context VWF, P-selectin, ICAM1 Adhesion and vascular interaction research

Coagulation Cascade and Thrombin Generation Targets

Coagulation factor antibodies help researchers evaluate cascade components, activation steps, and regulatory proteins. Targets may include F2/prothrombin, thrombin, F3/tissue factor, F5, F7, F8, F9, F10, F11, F12, SERPINC1/antithrombin, protein C, protein S, and related pathway markers. Thrombin generation markers are presented as research readouts, not clinical interpretation tools.

  • Initiation-focused panels may include tissue factor, F7, and early cascade markers.
  • Propagation and thrombin-generation studies may use F2, thrombin, F5, F8, F9, and F10-related targets.
  • Regulatory pathway studies may include antithrombin, thrombomodulin, protein C, protein S, and TFPI.
  • Assay planning can consider sample matrix, target state, antibody specificity, and validation conditions.

Fibrin Formation, Fibrinolysis, and Clot Structure

Fibrinogen antibody and fibrin-related target searches are central to clot-formation studies. Researchers may need antibodies against FGA, FGB, FGG, fibrin, fibrin degradation-associated markers, plasminogen, PLAT/tPA, PLAU/uPA, SERPINE1/PAI-1, and proteins involved in clot structure or fibrinolysis.

Endothelial and Hemostatic Regulation Markers

Hemostasis is not only a platelet and coagulation process; the vessel wall contributes through VWF, thrombomodulin, EPCR/PROCR, TFPI, endothelial activation markers, and anticoagulant regulation pathways. A von Willebrand factor antibody may be used in research contexts involving platelet adhesion, endothelial storage/release biology, or vascular hemostatic regulation.

Research focus Representative antibody targets Common research use
Endothelial hemostasis VWF, THBD, PROCR, TFPI Vessel-wall contribution to coagulation and anticoagulant regulation
Clot formation Fibrinogen chains, fibrin, thrombin Fibrin formation and clot-structure studies
Fibrinolysis PLG, PLAT, PLAU, SERPINE1 Clot breakdown and fibrinolytic pathway research

Browse Thrombosis and Hemostasis Antibodies by Target

Researchers can browse products by platelet activation, coagulation factors, fibrin formation, fibrinolysis, endothelial hemostatic regulation, and anticoagulant pathways. Hot Products may include VWF, PF4, fibrinogen chains, thrombin, tissue factor, CD41, CD61, CD62P, antithrombin, thrombomodulin, and PAI-1.

FAQ

Which antibodies are useful for platelet activation studies?

CD41, CD61, CD62P/P-selectin, GP1BA, GP6, PF4/CXCL4, and thrombospondin are commonly considered for platelet identity, activation, adhesion, and granule-release research. The right choice depends on assay format and activation model.

How should coagulation factor antibodies be selected?

Start with the cascade step being studied. Tissue factor and F7 may support initiation-focused studies, F2/thrombin and factors V, VIII, IX, and X may support propagation questions, while antithrombin, protein C/S, TFPI, and thrombomodulin relate to regulation.

What is the difference between fibrinogen and fibrin antibody use?

Fibrinogen antibodies may detect precursor protein chains or circulating fibrinogen-related targets, while fibrin-focused antibodies are more relevant to clot structure and fibrin deposition studies. Validation details should be checked for the intended sample and assay.

Can VWF and PF4 antibodies support hemostasis research?

Yes. VWF is relevant to platelet adhesion and endothelial hemostatic regulation, while PF4/CXCL4 is commonly associated with platelet granule release and platelet activation research. Both should be used within research-use-only settings.

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Target: F13A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB49A
Application*: WB, P, F
Target: SELP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB359
Application*: IF, FC
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB271
Application*: IF, FC
Target: SELP
Host: Rat
Antibody Isotype: IgG1, λ
Specificity: Mouse
Clone: RB40.34
Application*: F
Target: PROCR
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: RCR-16
Application*: F
Target: ITGB3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: RUU-PL7F12
Application*: F
Target: GP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: Z1
Application*: E, F, IH, WB
Target: TFPI
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0249
Application*: F, IA, WB
Target: PLAU
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 204212
Application*: WB, IP, E-capture
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG2
Specificity: Cattle
Clone: IVA30
Application*: E, F, IP
Target: ITGB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: F11
Application*: F, C, IP
Target: VWF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: R/2
Application*: E, F, IH, IF, IP, FN, R, WB
Target: SERPINE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MA-33H1F7
Application*: FN, WB
Target: ITGB3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1867
Application*: F, IH
Target: ITGA2B
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0814
Application*: F
Target: SELP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: AK-6
Application*: WB, F, IC, IF, P, C
Target: PROCR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1G8
Application*: WB
Target: PLAUR
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 10K37
Application*: F
Target: PLAT
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYC-P421
Application*: E, WB
Target: PF4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: KKO
Application*: E, WB
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For Research Use Only. Not For Clinical Use.
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