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Mouse Anti-Peroxiredoxin 1/Prdx1 Recombinant Antibody (6A6-4H3-7A3) (CBMAB-Z0247-LY)

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Basic Information

Host Animal
Mouse
Clone
6A6-4H3-7A3
Application
WB, IHC-P, IF
Immunogen
Recombinant Protein of Peroxiredoxin-1
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
peroxiredoxin 1
Entrez Gene ID
Human5052
Mouse18477
Rat117254
UniProt ID
HumanQ06830
MouseP35700
RatQ63716
Alternative Names
Hbp23, Heme binding 23kDa protein, Macrophage stress protein 22kDa, MSP23, NKEF A, Prdx1
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2 (PubMed:9497357).
Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).
Biological Process
Cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Cell redox homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Erythrocyte homeostasisIEA:Ensembl
Hydrogen peroxide catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Leukocyte activationManual Assertion Based On ExperimentIBA:GO_Central
Natural killer cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Natural killer cell mediated cytotoxicityIEA:Ensembl
Regulation of NIK/NF-kappaB signalingIEA:Ensembl
Regulation of stress-activated MAPK cascadeIEA:Ensembl
Removal of superoxide radicalsManual Assertion Based On ExperimentIBA:GO_Central
Retina homeostasisManual Assertion Based On ExperimentHEP:UniProtKB
Skeletal system developmentManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
PTM
Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity.
The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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