ACSL1

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. [provided by RefSeq]

Full Name

acyl-CoA synthetase long-chain family member 1

Function

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate. Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs) (By similarity).

Biological Process

Adiponectin-activated signaling pathway
Alpha-linolenic acid metabolic process
Fatty acid transport
Linoleic acid metabolic process
Lipid biosynthetic process
Long-chain fatty acid import into cell
Long-chain fatty acid metabolic process
Long-chain fatty-acyl-CoA biosynthetic process
Positive regulation of cold-induced thermogenesis
Positive regulation of long-chain fatty acid import across plasma membrane
Positive regulation of protein serine/threonine kinase activity
Regulation of metabolic process
Response to drug
Response to nutrient
Response to oleic acid
Response to organic cyclic compound
Triglyceride biosynthetic process
Very long-chain fatty acid metabolic process
Xenobiotic catabolic process

Cellular Location

Peroxisome membrane; Microsome membrane; Endoplasmic reticulum membrane; Mitochondrion outer membrane

Topology

Helical: 25-45 aa
Cytoplasmic: 46-698 aa