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ADD1

Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. [provided by RefSeq, Aug 2017]

Full Name

Adducin 1

Function

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.

Biological Process

Actin cytoskeleton organization
Actin filament bundle assembly
Barbed-end actin filament capping
Cell morphogenesis
Cellular response to calcium ion
Cell volume homeostasis
Erythrocyte differentiation
Hemoglobin metabolic process
Homeostasis of number of cells within a tissue
In utero embryonic development
IRE1-mediated unfolded protein response
Multicellular organism growth
Positive regulation of adherens junction organization
Positive regulation of establishment of endothelial barrier
Positive regulation of protein binding
Transmembrane transport

Cellular Location

Cell membrane; Cytoskeleton

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Anti-ADD1 antibodies

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Rabbit Anti-ADD1 Recombinant Antibody (V2-179872) (CBMAB-A1252-YC)

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Target: ADD1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Monkey

Clone: V2-179872

Application*: WB, IP

Mouse Anti-ADD1 Recombinant Antibody (V2-179871) (CBMAB-A1250-YC)

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Target: ADD1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: V2-179871

Application*: E, IH, WB

Mouse Anti-ADD1 Recombinant Antibody (CBT2090) (V2LY-0625-LY243)

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Target: ADD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT2090

Application*: IH

ADD1 Matched Antibody Pair (025) (APMAB-025LY)

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Target: ADD1

Specificity: Human

Mouse Anti-ADD1 Recombinant Antibody (V2-12523) (CBMAB-1013-CN)

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Target: ADD1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: V2-12523

Application*: WB, E, F, IH, MC, IC

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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