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Mouse Anti-ADD1 Recombinant Antibody (CBT2090) (V2LY-0625-LY243)


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Tested Data
Mouse Anti-ADD1 Recombinant Antibody (CBT2090) (V2LY-0625-LY243) in ELISA
Mouse Anti-ADD1 Recombinant Antibody (CBT2090) (V2LY-0625-LY243) in ELISA
Mouse Anti-ADD1 Recombinant Antibody (CBT2090) (V2LY-0625-LY243) in WB
Mouse Anti-ADD1 Recombinant Antibody (CBT2090) (V2LY-0625-LY243) in WB
Mouse Anti-ADD1 Recombinant Antibody (CBT2090) (V2LY-0625-LY243) in WB
Mouse Anti-ADD1 Recombinant Antibody (CBT2090) (V2LY-0625-LY243) in WB
Mouse Anti-ADD1 Recombinant Antibody (CBT2090) (V2LY-0625-LY243) in IHC
Mouse Anti-ADD1 Recombinant Antibody (CBT2090) (V2LY-0625-LY243) in IHC
Mouse Anti-ADD1 Recombinant Antibody (CBT2090) (V2LY-0625-LY243) in IHC
Mouse Anti-ADD1 Recombinant Antibody (CBT2090) (V2LY-0625-LY243) in IHC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2090
Antibody Isotype
IgG1
Application
IHC

Basic Information

Immunogen
Purified recombinant fragment of human ADD1 (AA: 1-193) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Adducin 1
Entrez Gene ID
118
UniProt ID
P35611
Function
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
Biological Process
Actin cytoskeleton organization
Actin filament bundle assembly
Barbed-end actin filament capping
Cell morphogenesis
Cellular response to calcium ion
Cell volume homeostasis
Erythrocyte differentiation
Hemoglobin metabolic process
Homeostasis of number of cells within a tissue
In utero embryonic development
IRE1-mediated unfolded protein response
Multicellular organism growth
Positive regulation of adherens junction organization
Positive regulation of establishment of endothelial barrier
Positive regulation of protein binding
Transmembrane transport
Cellular Location
Cell membrane; Cytoskeleton
More Infomation

Yermolenko, S., Chumachenko, Y., Orlovskyi, V., Moiseyenko, I., & Orlovskyi, O. (2021). The Association between Gly460Trp-Polymorphism of Alpha-Adducin 1 Gene (ADD1) and Arterial Hypertension Development in Ukrainian Population. International Journal of Hypertension, 2021.

Su, C. Y., Yan, R. L., Hsu, W. H., Chu, C. T., Chang, H. C., Lai, C. C., ... & Chen, H. C. (2019). Phosphorylation of adducin-1 by cyclin-dependent kinase 5 is important for epidermal growth factor-induced cell migration. Scientific reports, 9(1), 1-11.

Gupta, S., Jhawat, V., Agarwal, B. K., Roy, P., & Saini, V. (2019). Alpha adducin (ADD1) gene polymorphism and new onset of diabetes under the influence of selective antihypertensive therapy in essential hypertension. Current hypertension reviews, 15(2), 123-134.

Hsu, W. H., Wang, W. J., Lin, W. Y., Huang, Y. M., Lai, C. C., Liao, J. C., & Chen, H. C. (2018). Adducin‐1 is essential for spindle pole integrity through its interaction with TPX2. EMBO reports, 19(8), e45607.

Park, M. Y., & Lee, M. S. (2018). Effects of Sodium Intake on the Association between the Salt-Sensitive Gene, Alpha-Adducin 1 (ADD1), and Inflammatory Cytokines in the Prevalence of Children Obesity. Journal of Lipid and Atherosclerosis, 7(2), 98-109.

Bayoumy, N. M., El-Shabrawi, M. M., Leheta, O. F., & Omar, H. H. (2017). α-Adducin gene promoter DNA methylation and the risk of essential hypertension. Clinical and Experimental Hypertension, 39(8), 764-768.

Luo, C., & Shen, J. (2017). Adducin in tumorigenesis and metastasis. Oncotarget, 8(29), 48453.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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