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Mouse Anti-ADD1 Recombinant Antibody (V2-179871) (CBMAB-A1250-YC)

Provided herein is a Mouse monoclonal antibody against Human Adducin 1. The antibody can be used for immunoassay techniques, such as ELISA, IHC, WB.
See all ADD1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-179871
Antibody Isotype
IgG1, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa1-662 from human ADD1 (AAH42998) with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC-P3 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-662

Target

Full Name
Adducin 1
Introduction
Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-add
Entrez Gene ID
118
UniProt ID
P35611
Alternative Names
Adducin 1; Adducin 1 (Alpha); Alpha-Adducin; ADDA; Erythrocyte Adducin Alpha Subunit; Erythrocyte Adducin Subunit Alpha;
Function
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
Biological Process
Actin cytoskeleton organization
Actin filament bundle assembly
Barbed-end actin filament capping
Cell morphogenesis
Cellular response to calcium ion
Cell volume homeostasis
Erythrocyte differentiation
Hemoglobin metabolic process
Homeostasis of number of cells within a tissue
In utero embryonic development
IRE1-mediated unfolded protein response
Multicellular organism growth
Positive regulation of adherens junction organization
Positive regulation of establishment of endothelial barrier
Positive regulation of protein binding
Transmembrane transport
Cellular Location
Cell membrane; Cytoskeleton

Yermolenko, S., Chumachenko, Y., Orlovskyi, V., Moiseyenko, I., & Orlovskyi, O. (2021). The Association between Gly460Trp-Polymorphism of Alpha-Adducin 1 Gene (ADD1) and Arterial Hypertension Development in Ukrainian Population. International Journal of Hypertension, 2021.

Su, C. Y., Yan, R. L., Hsu, W. H., Chu, C. T., Chang, H. C., Lai, C. C., ... & Chen, H. C. (2019). Phosphorylation of adducin-1 by cyclin-dependent kinase 5 is important for epidermal growth factor-induced cell migration. Scientific reports, 9(1), 1-11.

Gupta, S., Jhawat, V., Agarwal, B. K., Roy, P., & Saini, V. (2019). Alpha adducin (ADD1) gene polymorphism and new onset of diabetes under the influence of selective antihypertensive therapy in essential hypertension. Current hypertension reviews, 15(2), 123-134.

Hsu, W. H., Wang, W. J., Lin, W. Y., Huang, Y. M., Lai, C. C., Liao, J. C., & Chen, H. C. (2018). Adducin‐1 is essential for spindle pole integrity through its interaction with TPX2. EMBO reports, 19(8), e45607.

Park, M. Y., & Lee, M. S. (2018). Effects of Sodium Intake on the Association between the Salt-Sensitive Gene, Alpha-Adducin 1 (ADD1), and Inflammatory Cytokines in the Prevalence of Children Obesity. Journal of Lipid and Atherosclerosis, 7(2), 98-109.

Bayoumy, N. M., El-Shabrawi, M. M., Leheta, O. F., & Omar, H. H. (2017). α-Adducin gene promoter DNA methylation and the risk of essential hypertension. Clinical and Experimental Hypertension, 39(8), 764-768.

Luo, C., & Shen, J. (2017). Adducin in tumorigenesis and metastasis. Oncotarget, 8(29), 48453.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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