ADM

The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]

Full Name

Adrenomedullin

Function

AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Adrenomedullin receptor signaling pathway
Aging
Amylin receptor signaling pathway
Androgen metabolic process
Animal organ regeneration
Antibacterial humoral response
Antimicrobial humoral immune response mediated by antimicrobial peptide
Branching involved in labyrinthine layer morphogenesis
Defense response to Gram-negative bacterium
Defense response to Gram-positive bacterium
Developmental growth
Female pregnancy Source: Ensembl
G protein-coupled receptor internalization
G protein-coupled receptor signaling pathway
Heart development
Hormone secretion
Inflammatory response
Negative regulation of cell population proliferation
Negative regulation of inflammatory response to antigenic stimulus
Negative regulation of vascular permeability
Negative regulation of vasoconstriction
Neural tube closure
Neuron projection regeneration
Odontogenesis of dentin-containing tooth
Positive regulation of angiogenesis
Positive regulation of apoptotic process
Positive regulation of cell population proliferation
Positive regulation of cytosolic calcium ion concentration
Positive regulation of heart rate
Positive regulation of progesterone biosynthetic process
Positive regulation of vasculogenesis
Receptor internalization
Regulation of systemic arterial blood pressure
Regulation of the force of heart contraction
Regulation of urine volume
Response to cold
Response to glucocorticoid
Response to hypoxia
Response to insulin
Response to lipopolysaccharide
Response to starvation
Response to wounding
Signal transduction
Spongiotrophoblast layer development
Vascular associated smooth muscle cell development
Vasculogenesis

Cellular Location

Secreted