ADORA1

The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]

Full Name

Adenosine A1 Receptor

Function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

Biological Process

Activation of MAPKK activity
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Apoptotic signaling pathway
Cell-cell signaling
Cognition
Detection of temperature stimulus involved in sensory perception of pain
Excitatory postsynaptic potential
Fatty acid homeostasis
G protein-coupled receptor signaling pathway
Inflammatory response
Lipid catabolic process
Negative regulation of acute inflammatory response
Negative regulation of apoptotic process
Negative regulation of cell population proliferation
Negative regulation of circadian sleep/wake cycle, non-REM sleep
Negative regulation of glutamate secretion
Negative regulation of heart contraction
Negative regulation of hormone secretion
Negative regulation of leukocyte migration
Negative regulation of lipid catabolic process
Negative regulation of long-term synaptic depression
Negative regulation of long-term synaptic potentiation
Negative regulation of mucus secretion
Negative regulation of neurotrophin production
Negative regulation of renal sodium excretion
Negative regulation of synaptic transmission, GABAergic
Negative regulation of synaptic transmission, glutamatergic
Negative regulation of systemic arterial blood pressure
Nervous system development
Phagocytosis
Positive regulation of epidermal growth factor-activated receptor activity
Positive regulation of lipid catabolic process
Positive regulation of neuron death
Positive regulation of nucleoside transport
Positive regulation of peptide secretion
Positive regulation of potassium ion transport
Positive regulation of protein dephosphorylation
Positive regulation of systemic arterial blood pressure
Protein targeting to membrane
Regulation of cardiac muscle cell contraction
Regulation of glomerular filtration
Regulation of respiratory gaseous exchange by nervous system process
Regulation of sensory perception of pain
Relaxation of vascular associated smooth muscle
Response to hypoxia
Signal transduction
Temperature homeostasis
Triglyceride homeostasis

Cellular Location

Cell membrane

Topology

Extracellular: 1-10 aa
Helical: 11-33 aa
Cytoplasmic: 34-46 aa
Helical: 47-69 aa
Extracellular: 70-80 aa
Helical: 81-102 aa
Cytoplasmic: 103-123 aa
Helical: 124-146 aa
Extracellular: 147-176 aa
Helical: 177-201 aa
Cytoplasmic: 202-235 aa
Helical: 236-259 aa
Extracellular: 260-267 aa
Helical: 268-292 aa
Cytoplasmic: 293-326 aa