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Rabbit Anti-ADORA1 Recombinant Antibody (V2-12530) (CBMAB-1020-CN)

This product is a rabbit antibody that recognizes ADORA1 of human. The antibody EPR6179 can be used for immunoassay techniques such as: FC, IF, IHC-P, IP, WB.
See all ADORA1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
V2-12530
Antibody Isotype
IgG
Application
FC, IF, IHC-P, IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues in the extracellular domain of Adenosine A1 Receptor (Human)
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
49% PBS, 50% Glycerol, 0.05% BSA, pH 7.2
Preservative
0.01% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Adenosine A1 Receptor
Introduction
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. This protein is a receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
Entrez Gene ID
134
UniProt ID
P30542
Alternative Names
RDC7
Function
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
Biological Process
Activation of MAPKK activity
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Apoptotic signaling pathway
Cell-cell signaling
Cognition
Detection of temperature stimulus involved in sensory perception of pain
Excitatory postsynaptic potential
Fatty acid homeostasis
G protein-coupled receptor signaling pathway
Inflammatory response
Lipid catabolic process
Negative regulation of acute inflammatory response
Negative regulation of apoptotic process
Negative regulation of cell population proliferation
Negative regulation of circadian sleep/wake cycle, non-REM sleep
Negative regulation of glutamate secretion
Negative regulation of heart contraction
Negative regulation of hormone secretion
Negative regulation of leukocyte migration
Negative regulation of lipid catabolic process
Negative regulation of long-term synaptic depression
Negative regulation of long-term synaptic potentiation
Negative regulation of mucus secretion
Negative regulation of neurotrophin production
Negative regulation of renal sodium excretion
Negative regulation of synaptic transmission, GABAergic
Negative regulation of synaptic transmission, glutamatergic
Negative regulation of systemic arterial blood pressure
Nervous system development
Phagocytosis
Positive regulation of epidermal growth factor-activated receptor activity
Positive regulation of lipid catabolic process
Positive regulation of neuron death
Positive regulation of nucleoside transport
Positive regulation of peptide secretion
Positive regulation of potassium ion transport
Positive regulation of protein dephosphorylation
Positive regulation of systemic arterial blood pressure
Protein targeting to membrane
Regulation of cardiac muscle cell contraction
Regulation of glomerular filtration
Regulation of respiratory gaseous exchange by nervous system process
Regulation of sensory perception of pain
Relaxation of vascular associated smooth muscle
Response to hypoxia
Signal transduction
Temperature homeostasis
Triglyceride homeostasis
Cellular Location
Cell membrane
Topology
Extracellular: 1-10 aa
Helical: 11-33 aa
Cytoplasmic: 34-46 aa
Helical: 47-69 aa
Extracellular: 70-80 aa
Helical: 81-102 aa
Cytoplasmic: 103-123 aa
Helical: 124-146 aa
Extracellular: 147-176 aa
Helical: 177-201 aa
Cytoplasmic: 202-235 aa
Helical: 236-259 aa
Extracellular: 260-267 aa
Helical: 268-292 aa
Cytoplasmic: 293-326 aa

Hohoff, C., Kroll, T., Zhao, B., Kerkenberg, N., Lang, I., Schwarte, K., ... & Deckert, J. (2020). ADORA2A variation and adenosine A 1 receptor availability in the human brain with a focus on anxiety-related brain regions: modulation by ADORA1 variation. Translational psychiatry, 10(1), 1-11.

Wu, X., You, W., Wu, Z., Ye, F., & Chen, S. (2020). Zinc finger protein 91 loss induces cardiac hypertrophy through adenosine A1 receptor down‐regulation under pressure overload status. Journal of Cellular and Molecular Medicine, 24(17), 10189-10201.

Province, H. S., Xiao, C., Mogul, A. S., Sahoo, A., Jacobson, K. A., Piñol, R. A., ... & Reitman, M. L. (2020). Activation of neuronal adenosine A1 receptors causes hypothermia through central and peripheral mechanisms. PloS one, 15(12), e0243986.

Zhang, J., Hou, Y., Du, X. L., Chen, D., Sui, G., Qi, Y., ... & Yang, Y. (2020). ADORA 1-driven brain-sympathetic neuro-adipose connections control body weight and adipose lipid metabolism. Molecular Psychiatry, 1-15.

Choi, S. J., Ryu, E., Lee, S., Huh, S., Shin, Y. S., Kang, B. W., ... & Kang, H. (2019). Adenosine induces EBV lytic reactivation through ADORA1 in EBV-associated gastric carcinoma. International journal of molecular sciences, 20(6), 1286.

Mei, H. F., Poonit, N., Zhang, Y. C., Ye, C. Y., Cai, H. L., Yu, C. Y., ... & Cai, X. H. (2018). Activating adenosine A1 receptor accelerates PC12 cell injury via ADORA1/PKC/KATP pathway after intermittent hypoxia exposure. Molecular and cellular biochemistry, 446(1), 161-170.

Hackett, T. A. (2018). Adenosine A1 receptor mRNA expression by neurons and glia in the auditory forebrain. The Anatomical Record, 301(11), 1882-1905.

Fernández-Dueñas, V., Pérez-Arévalo, A., Altafaj, X., Ferré, S., & Ciruela, F. (2017). Adenosine A1-A2A receptor heteromer as a possible target for early-onset Parkinson's disease. Frontiers in neuroscience, 11, 652.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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