ALOX5AP

ALOX5AP is a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This pr

Full Name

Arachidonate 5-Lipoxygenase Activating Protein

Function

Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.

Biological Process

Cellular response to calcium ion Source: UniProtKB
Leukotriene biosynthetic process Source: UniProtKB
Leukotriene metabolic process Source: Reactome
Lipoxin biosynthetic process Source: Reactome
Lipoxygenase pathway Source: Reactome
Protein homotrimerization Source: UniProtKB

Cellular Location

Nucleus membrane; Endoplasmic reticulum membrane

Involvement in disease

Ischemic stroke (ISCHSTR): A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.

Topology

Lumenal: 1-8 aa
Helical: 9-30 aa
Cytoplasmic: 31-52 aa
Helical: 53-77 aa
Lumenal: 78-80 aa
Helical: 81-102 aa
Cytoplasmic: 103-107 aa
Helical: 108-115 aa
Lumenal: 116-128 aa
Helical: 129-161 aa