ANXA4

Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]

Annexin A4

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.

Epithelial cell differentiation Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of interleukin-8 production Source: BHF-UCL
Negative regulation of NF-kappaB transcription factor activity Source: BHF-UCL
Notch signaling pathway Source: Ensembl
Regulation of transcription by RNA polymerase II Source: BHF-UCL
Signal transduction Source: UniProtKB

Extracellular exosome; Nuclear membrane; Nucleus; Plasma membrane; Cell surface; Collagen-containing extracellular matrix; Cytoplasm; Perinuclear region of cytoplasm; Vesicle membrane