APAF1

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Full Name
Apoptotic Peptidase Activating Factor 1
Function
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: UniProtKB
Aging Source: Ensembl
Apoptotic process Source: ProtInc
Cardiac muscle cell apoptotic process Source: Ensembl
Cell differentiation Source: Ensembl
Cellular response to transforming growth factor beta stimulus Source: Ensembl
Forebrain development Source: Ensembl
Intrinsic apoptotic signaling pathway Source: UniProtKB
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: Ensembl
Kidney development Source: Ensembl
Negative regulation of G0 to G1 transition Source: Reactome
Nervous system development Source: ProtInc
Neural tube closure Source: Ensembl
Neuron apoptotic process Source: Ensembl
Neutrophil degranulation Source: Reactome
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of apoptotic signaling pathway Source: Ensembl
Regulation of apoptotic DNA fragmentation Source: Ensembl
Regulation of apoptotic process Source: UniProtKB
Response to G1 DNA damage checkpoint signaling Source: UniProtKB
Response to hypoxia Source: Ensembl
Response to nutrient Source: Ensembl
Cellular Location
Cytoplasm
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Anti-APAF1 antibodies

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Rabbit Anti-APAF1 Recombinant Antibody (CBYC-A656) (CBMAB-A3012-YC)

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Target: APAF1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-A656
Application*: WB, IP
Datasheet SDS

Mouse Anti-APAF1 Recombinant Antibody (5E11) (CBMAB-A3008-YC)

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Target: APAF1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 5E11
Application*: P, IC, IP, WB
Datasheet SDS

Mouse Anti-APAF1 Recombinant Antibody (5C1) (CBMAB-A3007-YC)

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Target: APAF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 5C1
Application*: WB
Datasheet SDS

Rat Anti-APAF1 Recombinant Antibody (2E12) (CBMAB-A3006-YC)

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Target: APAF1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2E12
Application*: E, IC, IP, WB
Datasheet SDS

Mouse Anti-APAF1 Recombinant Antibody (2E10) (CBMAB-A3005-YC)

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Target: APAF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 2E10
Application*: IH, WB
Datasheet SDS

Rat Anti-APAF1 Recombinant Antibody (18H2) (CBMAB-A3004-YC)

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Target: APAF1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: 18H2
Application*: E, IC, IP, WB
Datasheet SDS

Rat Anti-APAF1 Recombinant Antibody (13F11) (CBMAB-A3002-YC)

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Target: APAF1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 13F11
Application*: E, IC, IP, WB
Datasheet SDS

Mouse Anti-APAF1 Recombinant Antibody (CBLNA-116) (CBMAB-1085-CN)

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Target: APAF1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLNA-116
Application*: WB
Datasheet SDS

Mouse Anti-APAF1 Recombinant Antibody (CBT3095) (V2LY-0625-LY904)

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Target: APAF1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT3095
Application*: F
Datasheet SDS

Mouse Anti-APAF1 Recombinant Antibody (CBT4241) (V2LY-0625-LY826)

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Target: APAF1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT4241
Application*: IC, F
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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