ASPSCR1

The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X;17)(p11;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2011]
Full Name
ASPSCR1, UBX Domain Containing Tether For SLC2A4
Function
Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity).
Enhances VCP methylation catalyzed by VCPKMT.
Biological Process
Glucose homeostasis Source: Ensembl
Intracellular protein transport Source: Ensembl
Positive regulation of protein modification process Source: UniProtKB
Regulation of glucose import Source: Ensembl
Cellular Location
Cytoplasm; Nucleus; Endomembrane system; Endoplasmic reticulum-Golgi intermediate compartment membrane
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Anti-ASPSCR1 antibodies

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Mouse Anti-ASPSCR1 Recombinant Antibody (4A11A6G11) (CBMAB-AO1048LY)

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Target: ASPSCR1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: 4A11A6G11
Application*: WB, IP, IF, P
Datasheet SDS

Rabbit Anti-ASPSCR1 Recombinant Antibody (SR2139) (CBMAB-C1082-CN)

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Target: ASPSCR1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: SR2139
Application*: IH, WB
Datasheet SDS

Mouse Anti-ASPSCR1 Recombinant Antibody (3D10-1D11) (CBMAB-A3808-YC)

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Target: ASPSCR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3D10-1D11
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-ASPSCR1 Recombinant Antibody (CBT3207) (V2LY-0625-LY2080)

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Target: ASPSCR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBT3207
Application*: WB
Datasheet SDS

ASPSCR1 Matched Antibody Pair (111) (APMAB-111LY)

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Target: ASPSCR1
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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