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Mouse Anti-ASPSCR1 Recombinant Antibody (4A11A6G11) (CBMAB-AO1048LY)

The product is antibody recognizes ASPSCR1. The antibody 4A11A6G11 immunoassay techniques such as: WB.
See all ASPSCR1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
4A11A6G11
Antibody Isotype
IgG2b, κ
Application
WB, IP, IF, IHC-P

Basic Information

Immunogen
Recombinant TUG of mouse origin.
Specificity
Mouse
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ASPSCR1, UBX Domain Containing Tether For SLC2A4
Introduction
The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X;17)(p11;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2011]
Entrez Gene ID
68938
UniProt ID
Q8VBT9
Alternative Names
Tether containing UBX domain for GLUT4; Alveolar soft part sarcoma chromosomal region candidate gene 1 protein; Alveolar soft part sarcoma locus; Renal papillary cell carcinoma protein 17; UBX domain-containing protein 9; ASPL; RCC17; TUG; UBXD9; UBXN9; ASPSCR1
Function
Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity).
Enhances VCP methylation catalyzed by VCPKMT.
Biological Process
Glucose homeostasis Source: Ensembl
Intracellular protein transport Source: Ensembl
Positive regulation of protein modification process Source: UniProtKB
Regulation of glucose import Source: Ensembl
Cellular Location
Cytoplasm; Nucleus; Endomembrane system; Endoplasmic reticulum-Golgi intermediate compartment membrane

Wang, S., Pozner, A., Neison, M., Jones, K., & Shen, P. (2021). The role of the ASPL-TFE3 fusion protein in Alveolar Soft Part Sarcoma. Microscopy and Microanalysis, 27(S1), 1114-1116.

Coyne, G. O. S., Naqash, A. R., Sankaran, H., & Chen, A. P. (2021). Advances in the management of alveolar soft part sarcoma. Current problems in cancer, 45(4), 100775.

Yoshimatsu, Y., Noguchi, R., Tsuchiya, R., Sei, A., Sugaya, J., Fukushima, S., ... & Kondo, T. (2020). Establishment and characterization of NCC-ASPS1-C1: a novel patient-derived cell line of alveolar soft-part sarcoma. Human Cell, 33(4), 1302-1310.

Whaley, R. D., & Thompson, L. D. (2020). Primary thyroid gland alveolar soft part sarcoma. Head and neck pathology, 14(3), 701-706.

Dumont, S. N., Orbach, D., Coulomb-L’herminé, A., & Robin, Y. M. (2020). Alveolar Soft Part Sarcoma. In Rare Sarcomas (pp. 91-112). Springer, Cham.

Principe, D. R., Mohindra, N. A., Munshi, H. G., & Kamath, S. D. (2019). Alveolar soft part sarcoma mimics prostate cancer metastasis. Oxford medical case reports, 2019(12), 507-509.

Soheilifar, M. H., Taheri, R. A., Emameh, R. Z., Moshtaghian, A., Kooshki, H., & Motie, M. R. (2018). Molecular landscape in alveolar soft part sarcoma: implications for molecular targeted therapy. Biomedicine & Pharmacotherapy, 103, 889-896.

Rhee, D. S., Dunkel, I. J., Shukla, N. N., Walsh, M. F., Gilheeney, S. W., Price, A. P., ... & Heaton, T. E. (2017). Alveolar soft part sarcoma of the bladder with ASPSCR1-TFE3 gene fusion as a secondary malignancy. Journal of Pediatric Surgery Case Reports, 27, 19-22.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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