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ATG13

ATG13 is an autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and mitophagy.

Full Name

Autophagy Related 13

Function

Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.

Biological Process

Autophagosome assembly Source: UniProtKB
Macroautophagy Source: Reactome
Mitophagy Source: GO_Central
Piecemeal microautophagy of the nucleus Source: GO_Central
Positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
Protein localization to phagophore assembly site Source: GO_Central
Regulation of macroautophagy Source: Reactome
Response to mitochondrial depolarisation Source: Ensembl

Cellular Location

Cytosol; Preautophagosomal structure. Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation.

PTM

Phosphorylated by ULK1, ULK2 and mTOR. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. ULK1-mediated phosphorylation of ATG13 at Ser-355 is required for efficient clearance of depolarized mitochondria.

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Anti-ATG13 antibodies

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Mouse Anti-ATG13 Recombinant Antibody (A3901) (CBMAB-A3901-YC)

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Target: ATG13

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: A3901

Application*: WB, FC, E, IH

Human Recombinant ATG13 protein, GST Tag-1 (V2LY-0526-LY2194)

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Target: ATG13

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: Full Length

Tag: GST Tag

Human Recombinant ATG13 protein, GST Tag (V2LY-0526-LY2193)

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Target: ATG13

Expressed Host: E. coli

Sequence: Amino Acid: Full Length

Tag: GST Tag

Mouse Anti-ATG13 Recombinant Antibody (CBT3137) (V2LY-0625-LY380)

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Target: ATG13

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT3137

Application*: IH

Mouse Anti-ATG13 Recombinant Antibody (CBT4064) (V2LY-0625-LY378)

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Target: ATG13

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT4064

Application*: IC, F

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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