ATP1B2

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. [provided by RefSeq]

Full Name

ATPase, Na+/K+ transporting, beta 2 polypeptide

Function

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-2 subunit is not known.
Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.

Biological Process

Cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
Cell-substrate adhesion Source: ARUK-UCL
Cellular potassium ion homeostasis Source: BHF-UCL
Cellular sodium ion homeostasis Source: BHF-UCL
Ion transmembrane transport Source: Reactome
Lateral ventricle development Source: ARUK-UCL
Leukocyte migration Source: Reactome
Membrane repolarization Source: BHF-UCL
Motor behavior Source: ARUK-UCL
Negative regulation of glial cell migration Source: ARUK-UCL
Neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration Source: ARUK-UCL
Photoreceptor cell maintenance Source: ARUK-UCL
Plasma membrane bounded cell projection organization Source: ARUK-UCL
Positive regulation of ATPase activity Source: BHF-UCL
Positive regulation of neuron projection development Source: ARUK-UCL
Positive regulation of potassium ion import across plasma membrane Source: BHF-UCL
Positive regulation of potassium ion transmembrane transporter activity Source: BHF-UCL
Positive regulation of sodium ion export across plasma membrane Source: BHF-UCL
Potassium ion import across plasma membrane Source: BHF-UCL
Protein stabilization Source: BHF-UCL
Regulation of cardiac conduction Source: Reactome
Retina homeostasis Source: ARUK-UCL
Sodium ion export across plasma membrane Source: BHF-UCL
Third ventricle development Source: ARUK-UCL
Transport across blood-brain barrier Source: ARUK-UCL

Cellular Location

Cell membrane

Topology

Cytoplasmic: 1-39 aa
Helical: 40-67 aa
Extracellular: 68-290 aa