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Mouse Anti-ATP1B2 Recombinant Antibody (4E3) (CBMAB-1166-CN)

This product is a mouse antibody that recognizes ATP1B2 of human. The antibody 4E3 can be used for immunoassay techniques such as: WB, ELISA.
See all ATP1B2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4E3
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
ATP1B2 (NP_001669.3, aa. 84-193) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATPase, Na+/K+ transporting, beta 2 polypeptide
Introduction
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane.
Entrez Gene ID
UniProt ID
Alternative Names
AMOG
Function
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-2 subunit is not known.
Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.
Biological Process
Cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
Cell-substrate adhesion Source: ARUK-UCL
Cellular potassium ion homeostasis Source: BHF-UCL
Cellular sodium ion homeostasis Source: BHF-UCL
Ion transmembrane transport Source: Reactome
Lateral ventricle development Source: ARUK-UCL
Leukocyte migration Source: Reactome
Membrane repolarization Source: BHF-UCL
Motor behavior Source: ARUK-UCL
Negative regulation of glial cell migration Source: ARUK-UCL
Neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration Source: ARUK-UCL
Photoreceptor cell maintenance Source: ARUK-UCL
Plasma membrane bounded cell projection organization Source: ARUK-UCL
Positive regulation of ATPase activity Source: BHF-UCL
Positive regulation of neuron projection development Source: ARUK-UCL
Positive regulation of potassium ion import across plasma membrane Source: BHF-UCL
Positive regulation of potassium ion transmembrane transporter activity Source: BHF-UCL
Positive regulation of sodium ion export across plasma membrane Source: BHF-UCL
Potassium ion import across plasma membrane Source: BHF-UCL
Protein stabilization Source: BHF-UCL
Regulation of cardiac conduction Source: Reactome
Retina homeostasis Source: ARUK-UCL
Sodium ion export across plasma membrane Source: BHF-UCL
Third ventricle development Source: ARUK-UCL
Transport across blood-brain barrier Source: ARUK-UCL
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-39 aa
Helical: 40-67 aa
Extracellular: 68-290 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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