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ATRN

This gene encodes both membrane-bound and secreted protein isoforms. A membrane-bound isoform exhibits sequence similarity with the mouse mahogany protein, a receptor involved in controlling obesity. A secreted isoform is involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines.

Full Name

ATTRACTIN

Function

Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity).
Has a critical role in normal myelination in the central nervous system (By similarity).

Biological Process

Animal organ morphogenesis Source: GO_Central
Cell migration Source: GO_Central
Cerebellum development Source: Ensembl
Inflammatory response Source: UniProtKB-KW
Myelination Source: Ensembl
Pigmentation Source: Ensembl
Regulation of multicellular organism growth Source: Ensembl
Response to oxidative stress Source: Ensembl
Substrate adhesion-dependent cell spreading Source: GO_Central
Tissue development Source: GO_Central

Cellular Location

Isoform 1: Cell membrane
Isoform 2: Secreted
Isoform 3: Secreted

Topology

Extracellular: 84-1279 aa
Helical: 1280-1300 aa
Cytoplasmic: 1301-1429 aa

PTM

Heavily glycosylated.

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Anti-ATRN antibodies

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Mouse Anti-ATRN Recombinant Antibody (CBFYM-0876) (CBMAB-M1023-FY)

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Target: ATRN

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Mouse, Rat, Human

Clone: CBFYM-0876

Application*: WB, IP, IF, E

Mouse Anti-ATRN Recombinant Antibody (CBYC-A896) (CBMAB-A4147-YC)

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Target: ATRN

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: CBYC-A896

Application*: WB, IP, IF, E

Mouse Anti-ATRN Recombinant Antibody (D-8) (CBMAB-A4145-YC)

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Target: ATRN

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: D-8

Application*: WB, IP, IF, E

Mouse Anti-ATRN Recombinant Antibody (9H8) (CBMAB-A4144-YC)

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Target: ATRN

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 9H8

Application*: WB, IP

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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