Mouse Anti-ATRN Recombinant Antibody (CBYC-A896) (CBMAB-A4147-YC)

Name: Mouse Anti-ATRN Recombinant Antibody (CBYC-A896)
SKU: CBMAB-A4147-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYC-A896

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 877-950 mapping within an internal region of Attractin of human origin.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA	1:100-1:1,000
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

ATTRACTIN

Introduction

ATRN encodes both membrane-bound and secreted protein isoforms. A membrane-bound isoform exhibits sequence similarity with the mouse mahogany protein, a receptor involved in controlling obesity. A secreted isoform is involved in the initial immune cell cl

Entrez Gene ID

8455

UniProt ID

O75882

Alternative Names

Attractin; Mahogany Protein; Mahogany Homolog; DPPT-L; MGCA; Attractin-2; KIAA0548;

Function

Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity).
Has a critical role in normal myelination in the central nervous system (By similarity).

Biological Process

Animal organ morphogenesis Source: GO_Central
Cell migration Source: GO_Central
Cerebellum development Source: Ensembl
Inflammatory response Source: UniProtKB-KW
Myelination Source: Ensembl
Pigmentation Source: Ensembl
Regulation of multicellular organism growth Source: Ensembl
Response to oxidative stress Source: Ensembl
Substrate adhesion-dependent cell spreading Source: GO_Central
Tissue development Source: GO_Central

Cellular Location

Isoform 1: Cell membrane
Isoform 2: Secreted
Isoform 3: Secreted

Topology

Extracellular: 84-1279 aa
Helical: 1280-1300 aa
Cytoplasmic: 1301-1429 aa

PTM

Heavily glycosylated.

Nawaratne, V., Kudumala, S., Kakad, P. P., & Godenschwege, T. A. (2021). The conserved MASRPF motif in the Attractin homolog, Distracted, is required for association with Drosophila E3-ligase Mgrn1. microPublication Biology, 2021.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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