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Mouse Anti-ATRN Recombinant Antibody (9H8) (CBMAB-A4144-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
9H8
Antibody Isotype
IgG1, κ
Application
WB, IP

Basic Information

Immunogen
Attractin of human origin.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATTRACTIN
Introduction
ATRN encodes both membrane-bound and secreted protein isoforms. A membrane-bound isoform exhibits sequence similarity with the mouse mahogany protein, a receptor involved in controlling obesity. A secreted isoform is involved in the initial immune cell cl
Entrez Gene ID
8455
UniProt ID
O75882
Alternative Names
Attractin; Mahogany Protein; Mahogany Homolog; DPPT-L; MGCA; Attractin-2; KIAA0548;
Function
Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity).
Has a critical role in normal myelination in the central nervous system (By similarity).
Biological Process
Animal organ morphogenesis Source: GO_Central
Cell migration Source: GO_Central
Cerebellum development Source: Ensembl
Inflammatory response Source: UniProtKB-KW
Myelination Source: Ensembl
Pigmentation Source: Ensembl
Regulation of multicellular organism growth Source: Ensembl
Response to oxidative stress Source: Ensembl
Substrate adhesion-dependent cell spreading Source: GO_Central
Tissue development Source: GO_Central
Cellular Location
Isoform 1: Cell membrane
Isoform 2: Secreted
Isoform 3: Secreted
Topology
Extracellular: 84-1279 aa
Helical: 1280-1300 aa
Cytoplasmic: 1301-1429 aa
PTM
Heavily glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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