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Mouse Anti-ATRN Recombinant Antibody (CBFYM-0876) (CBMAB-M1023-FY)

This product is mouse antibody that recognizes ATRN. The antibody CBFYM-0876 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all ATRN antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBFYM-0876
Antibody Isotype
IgM, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 134-152 within an internal region of Attractin of mouse origin.
Specificity
Mouse, Rat, Human
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA1:100-1:1,000
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATTRACTIN
Introduction
This gene encodes both membrane-bound and secreted protein isoforms. A membrane-bound isoform exhibits sequence similarity with the mouse mahogany protein, a receptor involved in controlling obesity. A secreted isoform is involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines.
Entrez Gene ID
Human8455
Mouse11990
Rat83526
UniProt ID
HumanO75882
MouseQ9WU60
RatQ99J86
Alternative Names
Attractin; Mahogany Protein; Mahogany Homolog; DPPT-L; MGCA; Attractin-2; KIAA0548
Function
Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity).
Has a critical role in normal myelination in the central nervous system (By similarity).
Biological Process
Animal organ morphogenesis Source: GO_Central
Cell migration Source: GO_Central
Cerebellum development Source: Ensembl
Inflammatory response Source: UniProtKB-KW
Myelination Source: Ensembl
Pigmentation Source: Ensembl
Regulation of multicellular organism growth Source: Ensembl
Response to oxidative stress Source: Ensembl
Substrate adhesion-dependent cell spreading Source: GO_Central
Tissue development Source: GO_Central
Cellular Location
Isoform 1: Cell membrane
Isoform 2: Secreted
Isoform 3: Secreted
Topology
Extracellular: 84-1279 aa
Helical: 1280-1300 aa
Cytoplasmic: 1301-1429 aa
PTM
Heavily glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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