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BACE2

BACE2 is an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The prot

Full Name

Beta-Site APP-Cleaving Enzyme 2

Function

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142).

Biological Process

Amyloid-beta metabolic process Source: GO_Central
Astrocyte activation Source: Ensembl
Glucose homeostasis Source: UniProtKB
Membrane protein ectodomain proteolysis Source: UniProtKB
Negative regulation of amyloid precursor protein biosynthetic process Source: UniProtKB
Peptide hormone processing Source: UniProtKB
Proteolysis Source: UniProtKB

Cellular Location

Endoplasmic reticulum; Golgi apparatus; Endosome; Cell membrane

Topology

Extracellular: 21-473 aa
Helical: 474-494 aa
Cytoplasmic: 495-518 aa

PTM

Undergoes autoproteolytic cleavage.
Glycosylated.

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Anti-BACE2 antibodies

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Mouse Anti-BACE2 Recombinant Antibody (CBYY-1737) (CBMAB-2086-YY)

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Target: BACE2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYY-1737

Application*: IH, IF, WB

Mouse Anti-BACE2 Recombinant Antibody (H-3) (CBMAB-1186-CN)

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Target: BACE2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse, Rat

Clone: H-3

Application*: WB, P, IF, IP, E

Mouse Anti-BACE2 Recombinant Antibody (F-12) (CBMAB-1185-CN)

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Target: BACE2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: F-12

Application*: WB, IF, IP, E

Mouse Recombinant BACE2 protein, His Tag (V2LY-0526-LY7854)

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Target: BACE2

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-462

Tag: His Tag

Human Recombinant BACE2 protein, His Tag (V2LY-0526-LY2284)

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Target: BACE2

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 21-466

Tag: His Tag

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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