BACE2

BACE2 is an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The prot

Beta-Site APP-Cleaving Enzyme 2

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142).

Amyloid-beta metabolic process Source: GO_Central
Astrocyte activation Source: Ensembl
Glucose homeostasis Source: UniProtKB
Membrane protein ectodomain proteolysis Source: UniProtKB
Negative regulation of amyloid precursor protein biosynthetic process Source: UniProtKB
Peptide hormone processing Source: UniProtKB
Proteolysis Source: UniProtKB

Endoplasmic reticulum; Golgi apparatus; Endosome; Cell membrane

Extracellular: 21-473 aa
Helical: 474-494 aa
Cytoplasmic: 495-518 aa

Undergoes autoproteolytic cleavage.
Glycosylated.