Human Recombinant BACE2 protein, His Tag (V2LY-0526-LY2284)

Fujimoto, K., Yoshida, S., Tadano, G., Asada, N., Fuchino, K., Suzuki, S., ... & Kusakabe, K. I. (2021). Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective β-Secretase (BACE1) Inhibitors over BACE2. Journal of Medicinal Chemistry, 64(6), 3075-3085.

He, F., Yu, J., Yang, J., Wang, S., Zhuang, A., Shi, H., ... & Jia, R. (2021). m6A RNA hypermethylation-induced BACE2 boosts intracellular calcium release and accelerates tumorigenesis of ocular melanoma. Molecular Therapy.

Yen, Y. C., Kammeyer, A. M., Tirlangi, J., Ghosh, A. K., & Mesecar, A. D. (2021). A Structure-Based Discovery Platform for BACE2 and the Development of Selective BACE Inhibitors. ACS Chemical Neuroscience, 12(4), 581-588.

Wang, Z., Xu, Q., Cai, F., Liu, X., Wu, Y., & Song, W. (2019). BACE2, a conditional β-secretase, contributes to Alzheimer’s disease pathogenesis. JCI insight, 4(1).

Liu, F., Zhang, Y., Liang, Z., Sun, Q., Liu, H., Zhao, J., ... & Sun, X. (2018). Cleavage of potassium channel Kv2. 1 by BACE2 reduces neuronal apoptosis. Molecular psychiatry, 23(7), 1542-1554.

Alcarraz-Vizán, G., Castaño, C., Visa, M., Montane, J., Servitja, J. M., & Novials, A. (2017). BACE2 suppression promotes β-cell survival and function in a model of type 2 diabetes induced by human islet amyloid polypeptide overexpression. Cellular and Molecular Life Sciences, 74(15), 2827-2838.

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols