Sign in or Register   Sign in or Register
  |  

Mouse Anti-BACE2 Recombinant Antibody (F-12) (CBMAB-1185-CN)

This product is a mouse antibody that recognizes BACE2 of human. The antibody F-12 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all BACE2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
F-12
Antibody Isotype
IgG1, κ
Application
WB, IF, IP, ELISA

Basic Information

Immunogen
Amino acids 429-518 mapping near the C-terminus of BACE2 of human origin.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Beta-Site APP-Cleaving Enzyme 2
Introduction
This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Responsible for the proteolytic processing of the amyloid precursor protein (APP). It has also been shown that it can cleave APP between residues 671 and 672.
Entrez Gene ID
25825
UniProt ID
Q9Y5Z0
Alternative Names
ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1
Function
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142).
Biological Process
Amyloid-beta metabolic process Source: GO_Central
Astrocyte activation Source: Ensembl
Glucose homeostasis Source: UniProtKB
Membrane protein ectodomain proteolysis Source: UniProtKB
Negative regulation of amyloid precursor protein biosynthetic process Source: UniProtKB
Peptide hormone processing Source: UniProtKB
Proteolysis Source: UniProtKB
Cellular Location
Endoplasmic reticulum; Golgi apparatus; Endosome; Cell membrane
Topology
Extracellular: 21-473 aa
Helical: 474-494 aa
Cytoplasmic: 495-518 aa
PTM
Undergoes autoproteolytic cleavage.
Glycosylated.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-BACE2 Recombinant Antibody (F-12)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare