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CBR1

The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]

Full Name

Carbonyl Reductase 1

Function

NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed:18449627, PubMed:15799708, PubMed:17912391, PubMed:7005231).
Can convert prostaglandin E to prostaglandin F2-alpha (By similarity).
Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed:18826943, PubMed:17344335).

Biological Process

Cyclooxygenase pathway Source: Reactome
Drug metabolic process Source: UniProtKB
Epithelial cell differentiation Source: UniProtKB
Positive regulation of reactive oxygen species metabolic process Source: UniProtKB
Vitamin K metabolic process Source: UniProtKB

Cellular Location

Cytoplasm

Anti-CBR1 antibodies

Mouse Anti-CBR1 Recombinant Antibody (CBXC-2085) (CBMAB-C4519-CQ)

SDS

Target: CBR1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXC-2085

Application*: WB, E, IF

Mouse Anti-CBR1 Recombinant Antibody (CBXC-0094) (CBMAB-C4518-CQ)

SDS

Target: CBR1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse

Clone: CBXC-0094

Application*: E, P, WB

Mouse Anti-CBR1 Recombinant Antibody (CBXC-2229) (CBMAB-C0216-CQ)

SDS

Target: CBR1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse

Clone: CBXC-2229

Application*: WB, E

Mouse Anti-CBR1 Recombinant Antibody (CBFYC-0891) (CBMAB-C0946-FY)

SDS

Target: CBR1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-0891

Application*: IC, WB

Mouse Anti-CBR1 Recombinant Antibody (2C9-B12-C4) (CBMAB-C12880-LY)

SDS

Target: CBR1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2C9-B12-C4

Application*: IC/IF, WB

Rabbit Anti-CBR1 Recombinant Antibody (EG498) (CBMAB-EN565-LY)

SDS

Target: CBR1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: EG498

Application*: WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000

Mouse Anti-CBR1 Recombinant Antibody (CAP1015) (CBMAB-AP841LY)

SDS

Target: CBR1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse

Clone: CAP1015

Application*: Dot blot, ELISA, WB

Mouse Anti-CBR1 Recombinant Antibody (CAP340) (CBMAB-AP840LY)

SDS

Target: CBR1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CAP340

Application*: ICC, WB

Mouse Anti-CBR1 Recombinant Antibody (CAP339) (CBMAB-AP839LY)

SDS

Target: CBR1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CAP339

Application*: ICC, WB

Mouse Anti-CBR1 Recombinant Antibody (CAP338) (CBMAB-AP838LY)

SDS

Target: CBR1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CAP338

Application*: ELISA, ICC, WB

Mouse Anti-CBR1 Recombinant Antibody (CB470A) (CBMAB-CA470LY)

SDS

Target: CBR1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CB470A

Application*: ELISA, WB, ICC

Mouse Anti-CBR1 Recombinant Antibody (CBCNC-146) (CBMAB-C1388-CN)

SDS

Target: CBR1

Host: Mouse

Specificity: Human

Clone: CBCNC-146

Application*: E, FC, IF, WB

Mouse Anti-CBR1 Recombinant Antibody (AT4E12) (CBMAB-C0453-CN)

SDS

Target: CBR1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: AT4E12

Application*: E, IH, WB

Mouse Anti-CBR1 Recombinant Antibody (4000000000000) (CBMAB-C0596-YY)

SDS

Target: CBR1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: 4000000000000

Application*: WB, E, IF

Mouse Anti-CBR1 Recombinant Antibody (4G11-1C7) (CBMAB-C6975-LY)

SDS

Target: CBR1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4G11-1C7

Application*: E, WB

Mouse Anti-CBR1 Recombinant Antibody (4D12-1G8) (CBMAB-C6777-LY)

SDS

Target: CBR1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4D12-1G8

Application*: E, WB

Mouse Anti-CBR1 Recombinant Antibody (2D6) (CBMAB-C4905-LY)

SDS

Target: CBR1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2D6

Application*: WB, E, IC/IF

Mouse Anti-CBR1 Recombinant Antibody (2C9B12C4) (CBMAB-C4832-LY)

SDS

Target: CBR1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2C9B12C4

Application*: WB, IC

Mouse Anti-CBR1 Recombinant Antibody (13k22) (CBMAB-C2934-LY)

SDS

Target: CBR1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 13k22

Application*: C, WB

Mouse Anti-CBR1 Recombinant Antibody (12L3) (CBMAB-C2689-LY)

SDS

Target: CBR1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 12L3

Application*: E, WB

Mouse Anti-CBR1 Recombinant Antibody (4E12) (CBMAB-C1931-LY)

SDS

Target: CBR1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse

Clone: 4E12

Application*: WB, E

CBR1 Matched Antibody Pair (190) (APMAB-190LY)

SDS

Target: CBR1

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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