CBR1

The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
Full Name
Carbonyl Reductase 1
Function
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed:18449627, PubMed:15799708, PubMed:17912391, PubMed:7005231).
Can convert prostaglandin E to prostaglandin F2-alpha (By similarity).
Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed:18826943, PubMed:17344335).
Biological Process
Cyclooxygenase pathway Source: Reactome
Drug metabolic process Source: UniProtKB
Epithelial cell differentiation Source: UniProtKB
Positive regulation of reactive oxygen species metabolic process Source: UniProtKB
Vitamin K metabolic process Source: UniProtKB
Cellular Location
Cytoplasm
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Anti-CBR1 antibodies

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Rabbit Anti-CBR1 Recombinant Antibody (EG498) (CBMAB-EN565-LY)

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Target: CBR1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: EG498
Application*: WB, P, E
Datasheet SDS

Mouse Anti-CBR1 Recombinant Antibody (CBXC-2229) (CBMAB-C0216-CQ)

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Target: CBR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBXC-2229
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CBR1 Recombinant Antibody (CBFYC-0891) (CBMAB-C0946-FY)

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Target: CBR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-0891
Application*: E, WB, IP
Datasheet SDS

Mouse Anti-CBR1 Recombinant Antibody (4G11-1C7) (CBMAB-C6975-LY)

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Target: CBR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4G11-1C7
Application*: E, WB
Datasheet SDS

Mouse Anti-CBR1 Recombinant Antibody (4D12-1G8) (CBMAB-C6777-LY)

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Target: CBR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4D12-1G8
Application*: E, WB
Datasheet SDS

Mouse Anti-CBR1 Recombinant Antibody (2D6) (CBMAB-C4905-LY)

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Target: CBR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2D6
Application*: WB, F, IC/IF
Datasheet SDS

Mouse Anti-CBR1 Recombinant Antibody (2C9B12C4) (CBMAB-C4832-LY)

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Target: CBR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C9B12C4
Application*: WB, IC
Datasheet SDS

Mouse Anti-CBR1 Recombinant Antibody (4E12) (CBMAB-C1931-LY)

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Target: CBR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: 4E12
Application*: WB, E
Datasheet SDS

CBR1 Matched Antibody Pair (190) (APMAB-190LY)

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Target: CBR1
Specificity: Human
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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