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CBR1 Matched Antibody Pair (190) (APMAB-190LY)

This antibody pair set can be used for detecting and quantifying protein level of human CBR1.
See all CBR1 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-CBR1 polyclonal antibody, 100 ug
Detection Antibody
Anti-CBR1 Mouse monoclonal, IgG2a antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
Alternative Names
Carbonyl Reductase 1; Short Chain Dehydrogenase/Reductase Family 21C Member 1; NADPH-Dependent Carbonyl Reductase 1; Prostaglandin-E(2) 9-Reductase; Prostaglandin 9-Ketoreductase; EC 1.1.1.184; SDR21C1; CBR; Short Chain Dehydrogenase/Reductase Family 21C, Member 1;
Entrez Gene ID
873
UniProt ID
P16152

Mao, L., Wang, K., Zhang, P., Ren, S., Sun, J., Yang, M., ... & Sun, B. (2021). Carbonyl Reductase 1 Attenuates Ischemic Brain Injury by Reducing Oxidative Stress and Neuroinflammation. Translational Stroke Research, 1-14.

Bell, R. M., Villalobos, E., Nixon, M., Miguelez-Crespo, A., Murphy, L., Fawkes, A., ... & Morgan, R. A. (2021). Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice. Molecular metabolism, 48, 101225.

Yun, M., Choi, A. J., Woo, S. R., Noh, J. K., Sung, J. Y., Lee, J. W., & Eun, Y. G. (2020). Inhibition of Carbonyl Reductase 1 Enhances Metastasis of Head and Neck Squamous Cell Carcinoma through β-catenin-Mediated Epithelial-Mesenchymal Transition. Journal of Cancer, 11(3), 533.

Koczurkiewicz-Adamczyk, P., Piska, K., Gunia-Krzyżak, A., Bucki, A., Jamrozik, M., Lorenc, E., ... & Pękala, E. (2020). Cinnamic acid derivatives as chemosensitising agents against DOX-treated lung cancer cells–Involvement of carbonyl reductase 1. European Journal of Pharmaceutical Sciences, 154, 105511.

Kajimura, T., Sato, S., Murakami, A., Hayashi‑Okada, M., Nakashima, K., Sueoka, K., & Sugino, N. (2019). Overexpression of carbonyl reductase 1 inhibits malignant behaviors and epithelial mesenchymal transition by suppressing TGF‑β signaling in uterine leiomyosarcoma cells. Oncology letters, 18(2), 1503-1512.

Seliger, J. M., Martin, H. J., Maser, E., & Hintzpeter, J. (2019). Potent inhibition of human carbonyl reductase 1 (CBR1) by the prenylated chalconoid xanthohumol and its related prenylflavonoids isoxanthohumol and 8-prenylnaringenin. Chemico-biological interactions, 305, 156-162.

Piska, K., Koczurkiewicz, P., Wnuk, D., Karnas, E., Bucki, A., Wójcik-Pszczoła, K., ... & Pękala, E. (2019). Synergistic anticancer activity of doxorubicin and piperlongumine on DU-145 prostate cancer cells–the involvement of carbonyl reductase 1 inhibition. Chemico-biological interactions, 300, 40-48.

Yun, M., Choi, A. J., Lee, Y. C., Kong, M., Sung, J. Y., Kim, S. S., & Eun, Y. G. (2018). Carbonyl reductase 1 is a new target to improve the effect of radiotherapy on head and neck squamous cell carcinoma. Journal of Experimental & Clinical Cancer Research, 37(1), 1-12.

Yamanouchi, R., Harada, K., Ferdous, T., & Ueyama, Y. (2018). Low carbonyl reductase 1 expression is associated with poor prognosis in patients with oral squamous cell carcinoma. Molecular and clinical oncology, 8(3), 400-406.

Shi, S. M., & Di, L. (2017). The role of carbonyl reductase 1 in drug discovery and development. Expert opinion on drug metabolism & toxicology, 13(8), 859-870.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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