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Mouse Anti-CBR1 Recombinant Antibody (CBFYC-0891) (CBMAB-C0946-FY)

This product is mouse antibody that recognizes CBR1. The antibody CBFYC-0891 can be used for immunoassay techniques such as: ICC, WB.
See all CBR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-0891
Antibody Isotype
IgG1
Application
ICC, WB

Basic Information

Immunogen
Purified recombinant human CBR1 protein fragments expressed in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.2% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Carbonyl Reductase 1
Introduction
The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene.
Entrez Gene ID
UniProt ID
Alternative Names
Carbonyl Reductase 1; Short Chain Dehydrogenase/Reductase Family 21C Member 1; NADPH-Dependent Carbonyl Reductase 1; Prostaglandin-E(2) 9-Reductase; Prostaglandin 9-Ketoreductase; EC 1.1.1.184; SDR21C1; CBR; Short Chain Dehydrogenase/Reductase Family 21C, Member 1
Function
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed:18449627, PubMed:15799708, PubMed:17912391, PubMed:7005231).
Can convert prostaglandin E to prostaglandin F2-alpha (By similarity).
Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed:18826943, PubMed:17344335).
Biological Process
Cyclooxygenase pathway Source: Reactome
Drug metabolic process Source: UniProtKB
Epithelial cell differentiation Source: UniProtKB
Positive regulation of reactive oxygen species metabolic process Source: UniProtKB
Vitamin K metabolic process Source: UniProtKB
Cellular Location
Cytoplasm

Mao, L., Wang, K., Zhang, P., Ren, S., Sun, J., Yang, M., ... & Sun, B. (2021). Carbonyl Reductase 1 Attenuates Ischemic Brain Injury by Reducing Oxidative Stress and Neuroinflammation. Translational Stroke Research, 1-14.

Bell, R. M., Villalobos, E., Nixon, M., Miguelez-Crespo, A., Murphy, L., Fawkes, A., ... & Morgan, R. A. (2021). Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice. Molecular metabolism, 48, 101225.

Yun, M., Choi, A. J., Woo, S. R., Noh, J. K., Sung, J. Y., Lee, J. W., & Eun, Y. G. (2020). Inhibition of Carbonyl Reductase 1 Enhances Metastasis of Head and Neck Squamous Cell Carcinoma through β-catenin-Mediated Epithelial-Mesenchymal Transition. Journal of Cancer, 11(3), 533.

Koczurkiewicz-Adamczyk, P., Piska, K., Gunia-Krzyżak, A., Bucki, A., Jamrozik, M., Lorenc, E., ... & Pękala, E. (2020). Cinnamic acid derivatives as chemosensitising agents against DOX-treated lung cancer cells–Involvement of carbonyl reductase 1. European Journal of Pharmaceutical Sciences, 154, 105511.

Kajimura, T., Sato, S., Murakami, A., Hayashi‑Okada, M., Nakashima, K., Sueoka, K., & Sugino, N. (2019). Overexpression of carbonyl reductase 1 inhibits malignant behaviors and epithelial mesenchymal transition by suppressing TGF‑β signaling in uterine leiomyosarcoma cells. Oncology letters, 18(2), 1503-1512.

Seliger, J. M., Martin, H. J., Maser, E., & Hintzpeter, J. (2019). Potent inhibition of human carbonyl reductase 1 (CBR1) by the prenylated chalconoid xanthohumol and its related prenylflavonoids isoxanthohumol and 8-prenylnaringenin. Chemico-biological interactions, 305, 156-162.

Piska, K., Koczurkiewicz, P., Wnuk, D., Karnas, E., Bucki, A., Wójcik-Pszczoła, K., ... & Pękala, E. (2019). Synergistic anticancer activity of doxorubicin and piperlongumine on DU-145 prostate cancer cells–the involvement of carbonyl reductase 1 inhibition. Chemico-biological interactions, 300, 40-48.

Yun, M., Choi, A. J., Lee, Y. C., Kong, M., Sung, J. Y., Kim, S. S., & Eun, Y. G. (2018). Carbonyl reductase 1 is a new target to improve the effect of radiotherapy on head and neck squamous cell carcinoma. Journal of Experimental & Clinical Cancer Research, 37(1), 1-12.

Yamanouchi, R., Harada, K., Ferdous, T., & Ueyama, Y. (2018). Low carbonyl reductase 1 expression is associated with poor prognosis in patients with oral squamous cell carcinoma. Molecular and clinical oncology, 8(3), 400-406.

Shi, S. M., & Di, L. (2017). The role of carbonyl reductase 1 in drug discovery and development. Expert opinion on drug metabolism & toxicology, 13(8), 859-870.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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