CD58
CD58 (CD58 Molecule) is a Protein Coding gene. Diseases associated with CD58 include Whipple Disease and Oral Lichen Planus. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include receptor binding.
Full Name
CD58 Molecule
Function
Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.
Biological Process
Cell-cell adhesion Source: UniProtKB
Cellular response to interferon-gamma Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Heterotypic cell-cell adhesion Source: UniProtKB
Leukocyte migration Source: Reactome
Neutrophil degranulation Source: Reactome
Positive regulation of interleukin-8 production Source: UniProtKB
Cellular response to interferon-gamma Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Heterotypic cell-cell adhesion Source: UniProtKB
Leukocyte migration Source: Reactome
Neutrophil degranulation Source: Reactome
Positive regulation of interleukin-8 production Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 29-215
Helical: 216-238
Cytoplasmic: 239-250
Helical: 216-238
Cytoplasmic: 239-250
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Anti-CD58 antibodies
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Target: CD58
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 13G5
Application*: E, WB
Target: CD58
Specificity: Human
Target: CD58
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: BRIC-5
Application*: F, WB
Target: CD58
Host: Rabbit
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0267
Application*: WB, IP
Target: CD58
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1369
Application*: E
Target: CD58
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-0472
Application*: E, WB
Target: CD58
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0381
Application*: F, IF
Target: CD58
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0168
Application*: F, IP, WB
Target: CD58
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-0167
Application*: F, IP, WB
Target: CD58
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2D11-B10
Application*: E, IF, P, WB
Target: CD58
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1015
Application*: P
Target: CD58
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 083
Application*: F, E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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