CD58

CD58 (CD58 Molecule) is a Protein Coding gene. Diseases associated with CD58 include Whipple Disease and Oral Lichen Planus. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include receptor binding.
Full Name
CD58 Molecule
Function
Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.
Biological Process
Cell-cell adhesion Source: UniProtKB
Cellular response to interferon-gamma Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Heterotypic cell-cell adhesion Source: UniProtKB
Leukocyte migration Source: Reactome
Neutrophil degranulation Source: Reactome
Positive regulation of interleukin-8 production Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 29-215
Helical: 216-238
Cytoplasmic: 239-250
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Anti-CD58 antibodies

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Target: CD58
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 13G5
Application*: E, WB
Target: CD58
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: BRIC-5
Application*: F, WB
Target: CD58
Host: Rabbit
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0267
Application*: WB, IP
Target: CD58
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1369
Application*: E
Target: CD58
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-0472
Application*: E, WB
Target: CD58
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0381
Application*: F, IF
Target: CD58
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0168
Application*: F, IP, WB
Target: CD58
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-0167
Application*: F, IP, WB
Target: CD58
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2D11-B10
Application*: E, IF, P, WB
Target: CD58
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1015
Application*: P
Target: CD58
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 083
Application*: F, E
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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