CEACAM8
CEACAM8 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 8) is a Protein Coding gene. Diseases associated with CEACAM8 include Endocarditis and Shwartzman Phenomenon. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. An important paralog of this gene is CEACAM6.
Full Name
Carcinoembryonic Antigen Related Cell Adhesion Molecule 8
Function
Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner (PubMed:8776764, PubMed:2022629, PubMed:11590190).
Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:8776764, PubMed:2022629, PubMed:11590190).
Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764).
Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:8776764, PubMed:2022629, PubMed:11590190).
Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764).
Biological Process
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Immune response Source: ProtInc
Leukocyte migration Source: Reactome
Neutrophil degranulation Source: Reactome
Immune response Source: ProtInc
Leukocyte migration Source: Reactome
Neutrophil degranulation Source: Reactome
Cellular Location
Cell membrane; Cell surface
PTM
Glycosylated.
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Anti-CEACAM8 antibodies
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Target: CEACAM8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6/40c
Application*: WB, F, E, IH, IP
Target: CEACAM8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1859
Application*: F, IH, WB
Target: CEACAM8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0204
Application*: F, IH, IF
Target: CEACAM8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 13
Application*: E
Target: CEACAM8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4
Application*: E, WB
Target: CEACAM8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 24H12
Application*: E, F
Target: CEACAM8
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: 22H9
Application*: E
Target: CEACAM8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2370
Application*: WB
Target: CEACAM8
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0798
Application*: F, IH, IF
Target: CEACAM8
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse
Clone: CBXC-1352
Application*: F, IH, IF
Target: CEACAM8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-0064
Application*: WB, IP, F, E
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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