Mouse Anti-CEACAM8 Recombinant Antibody (6/40c) (CBMAB-AP1445LY)

Name: Mouse Anti-CEACAM8 Recombinant Antibody (6/40c)
SKU: CBMAB-AP1445LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

6/40c

Application

WB, FC, ELISA, IHC, IP

Immunogen

Recombinant soluble human CEACAM8-Fc produced in HEK293 cells.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:2,000
ELISA	1:100-1:2,000
IHC	1:100-1:500
IP	1:10-1:500
FC	1:10-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Carcinoembryonic Antigen Related Cell Adhesion Molecule 8

Introduction

CEACAM8 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 8) is a Protein Coding gene. Diseases associated with CEACAM8 include Endocarditis and Shwartzman Phenomenon. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. An important paralog of this gene is CEACAM6.

Entrez Gene ID

1088

UniProt ID

P31997

Alternative Names

Carcinoembryonic Antigen Related Cell Adhesion Molecule 8; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 8; Non-Specific Cross-Reacting Antigen NCA-95; Carcinoembryonic Antigen CGM6; CD67 Antigen; CGM6;

Function

Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner (PubMed:8776764, PubMed:2022629, PubMed:11590190).
Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:8776764, PubMed:2022629, PubMed:11590190).
Heterophilic interaction with CEACAM8 ^oCcurs in activated neutrophils (PubMed:8776764).

Biological Process

Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Immune response Source: ProtInc
Leukocyte migration Source: Reactome
Neutrophil degranulation Source: Reactome

Cellular Location

Cell membrane; Cell surface

PTM

Glycosylated.

Ribon, M., Mussard, J., Semerano, L., Singer, B. B., & Decker, P. (2019). Extracellular chromatin triggers release of soluble CEACAM8 upon activation of neutrophils. Frontiers in immunology, 10, 1346.

Iwabuchi, E., Miki, Y., Takagi, K., Onodera, Y., Shibahara, Y., Ishida, T., ... & Sasano, H. (2019). The expression of carcinoembryonic antigen-related cell adhesion molecule 6 and 8 in breast cancer.

Iwabuchi, E., Miki, Y., Onodera, Y., Shibahara, Y., Takagi, K., Suzuki, T., ... & Sasano, H. (2019). Co-expression of carcinoembryonic antigen-related cell adhesion molecule 6 and 8 inhibits proliferation and invasiveness of breast carcinoma cells. Clinical & experimental metastasis, 36(5), 423-432.

Zaghloul, A., Kamal, H., Ismail, M. M., Teama, S. H., & Abdulateef, N. A. (2018). Soluble carcinoembryonic antigen cell adhesion molecule 1, 6 and 8 in acute myeloid leukemia: their relation to survival and prognosis. Life Science Journal, 15(4).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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