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Mouse Anti-CEACAM8 Recombinant Antibody (CBXC-1352) (CBMAB-C1621-CQ)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
CBXC-1352
Application
FC, IHC, IF
Immunogen
Human peripheral blood cells.
Host Species
Mouse
Specificity
Human, Mouse
Antibody Isotype
IgM, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC1:10-1:500
FC1 µg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.05% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Carcinoembryonic Antigen Related Cell Adhesion Molecule 8
Introduction
CEACAM8 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 8) is a Protein Coding gene. Diseases associated with CEACAM8 include Endocarditis and Shwartzman Phenomenon. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. An important paralog of this gene is CEACAM6.
Entrez Gene ID
1088
UniProt ID
P31997
Alternative Names
Carcinoembryonic Antigen Related Cell Adhesion Molecule 8; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 8; Non-Specific Cross-Reacting Antigen NCA-95; Carcinoembryonic Antigen CGM6; CD67 Antigen; CGM6;
Function
Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner (PubMed:8776764, PubMed:2022629, PubMed:11590190).
Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:8776764, PubMed:2022629, PubMed:11590190).
Heterophilic interaction with CEACAM8 oCcurs in activated neutrophils (PubMed:8776764).
Biological Process
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Immune response Source: ProtInc
Leukocyte migration Source: Reactome
Neutrophil degranulation Source: Reactome
Cellular Location
Cell membrane; Cell surface
PTM
Glycosylated.

Ribon, M., Mussard, J., Semerano, L., Singer, B. B., & Decker, P. (2019). Extracellular chromatin triggers release of soluble CEACAM8 upon activation of neutrophils. Frontiers in immunology, 10, 1346.

Iwabuchi, E., Miki, Y., Takagi, K., Onodera, Y., Shibahara, Y., Ishida, T., ... & Sasano, H. (2019). The expression of carcinoembryonic antigen-related cell adhesion molecule 6 and 8 in breast cancer.

Iwabuchi, E., Miki, Y., Onodera, Y., Shibahara, Y., Takagi, K., Suzuki, T., ... & Sasano, H. (2019). Co-expression of carcinoembryonic antigen-related cell adhesion molecule 6 and 8 inhibits proliferation and invasiveness of breast carcinoma cells. Clinical & experimental metastasis, 36(5), 423-432.

Zaghloul, A., Kamal, H., Ismail, M. M., Teama, S. H., & Abdulateef, N. A. (2018). Soluble carcinoembryonic antigen cell adhesion molecule 1, 6 and 8 in acute myeloid leukemia: their relation to survival and prognosis. Life Science Journal, 15(4).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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