CHST12

Chondroitin 4-sulfotransferases, such as CHST12, add sulfate to position 4 of N-acetylgalactosamine residues in chondroitin (Hiraoka et al., 2000 [PubMed 10781601]).[supplied by OMIM

Full Name

carbohydrate (chondroitin 4) sulfotransferase 12

Function

Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.

Biological Process

Carbohydrate biosynthetic process Source: InterPro
Chondroitin sulfate biosynthetic process Source: UniProtKB
Dermatan sulfate biosynthetic process Source: UniProtKB
Proteoglycan biosynthetic process Source: GO_Central

Cellular Location

Golgi apparatus membrane

Topology

Cytoplasmic: 1-5
Helical: 6-26
Lumenal: 27-414