CLIC3

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. [provided by RefSeq, Jul 2008]

Chloride Intracellular Channel 3

Can insert into membranes and form chloride ion channels. May participate in cellular growth control.

Chloride transport Source: UniProtKB
Glutathione metabolic process Source: InterPro
Regulation of ion transmembrane transport Source: UniProtKB-KW
Signal transduction Source: ProtInc

Nucleus; Cytoplasm; Membrane. Predominantly nuclear. Some protein was found in the cytoplasm. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity).

Helical: 24-44