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Mouse Anti-CLIC3 Recombinant Antibody (CBCNC-024) (CBMAB-C0917-CN)


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Published Data
CBMAB-C0917-CN-1
Mouse Anti-CLIC3 Recombinant Antibody (CBCNC-024) (CBMAB-C0917-CN) in WB
Protein expression of CLIC3 in the rat plasma and brains. CLIC3 expression in the prefrontal cortex (PFC). ...View More
Zhu, X., Wang, C. L., Yu, J. F., Weng, J., Han, B., Liu, Y., ... & Pan, B. (2023). Identification of immune-related biomarkers in peripheral blood of schizophrenia using bioinformatic methods and machine learning algorithms. Frontiers in Cellular Neuroscience, 17, 1256184.
Distributed under Open Access license CC BY 4.0, without modification.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBCNC-024
Antibody Isotype
IgG2b, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 41-79 within an internal region of CLIC3 of human.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% gelatin
Preservative
<0.1% sodium azide
Concentration
0.2 mg/ml

Target

Full Name
Chloride Intracellular Channel 3
Introduction
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human9022
Mouse69454
Rat296566
UniProt ID
HumanO95833
MouseQ9D7P7
RatD3ZY91
Alternative Names
Chloride Intracellular Channel 3;
Function
Can insert into membranes and form chloride ion channels. May participate in cellular growth control.
Biological Process
Chloride transport Source: UniProtKB
Glutathione metabolic process Source: InterPro
Regulation of ion transmembrane transport Source: UniProtKB-KW
Signal transduction Source: ProtInc
Cellular Location
Nucleus; Cytoplasm; Membrane. Predominantly nuclear. Some protein was found in the cytoplasm. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity).
Topology
Helical: 24-44
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For research use only. Not intended for any clinical use.

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