Mouse Anti-CLIC3 Recombinant Antibody (2C5) (V2LY-1206-LY221)

Name: Mouse Anti-CLIC3 Recombinant Antibody (2C5)
SKU: V2LY-1206-LY221
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

2C5

Antibody Isotype

IgG1, κ

Application

ELISA, WB

Basic Information

Immunogen

CLIC3 (137 a.a. ~ 236 a.a) partial recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Chloride Intracellular Channel 3

Entrez Gene ID

9022

UniProt ID

O95833

Function

Can insert into membranes and form chloride ion channels. May participate in cellular growth control.

Biological Process

Chloride transport Source: UniProtKB
Glutathione metabolic process Source: InterPro
Regulation of ion transmembrane transport Source: UniProtKB-KW
Signal transduction Source: ProtInc

Cellular Location

Nucleus; Cytoplasm; Membrane. Predominantly nuclear. Some protein was found in the cytoplasm. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity).

Topology

Helical: 24-44

More Infomation

References

Kawai, S., Fujii, T., Shimizu, T., Sukegawa, K., Hashimoto, I., Okumura, T., ... & Fujii, T. (2020). Pathophysiological properties of CLIC3 chloride channel in human gastric cancer cells. The Journal of Physiological Sciences, 70(1), 1-11.

Chen, M., Zhang, S., Wen, X., Cao, H., & Gao, Y. (2020). Prognostic value of CLIC3 mRNA overexpression in bladder cancer. PeerJ, 8, e8348.

Liang, J., Long, Z., Zhang, Y., Chen, X., Zhang, T., Hu, Z., ... & Zheng, Y. (2019). Polarization to Anti-Inflammatory Status of Macrophages Predicts Poor Prognosis of HBV-Related Acute-on-Chronic Liver Failure Patients via Chloride Intercellular Channel 3 Suppression. Available at SSRN 3363780.

Hernandez-Fernaud, J. R., Ruengeler, E., Casazza, A., Neilson, L. J., Pulleine, E., Santi, A., ... & Zanivan, S. (2017). Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity. Nature communications, 8(1), 1-17.

Norman, J., & Zanivan, S. (2017). Chloride intracellular channel 3: A secreted pro-invasive oxidoreductase. Cell Cycle, 16(21), 1993-1994.

Brum, A. M., van der Leije, C. S., Schreuders‐Koedam, M., Verhoeven, J., Janssen, M., Dekkers, D. H., ... & van der Eerden, B. C. (2017). Identification of chloride intracellular channel protein 3 as a novel gene affecting human bone formation. JBMR plus, 1(1), 16-26.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Antibody Pairs

CLIC3 Matched Antibody Pair (276)

CLIC3 Matched Antibody Pair (277)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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