CTR9

CTR9 (CTR9 Homolog, Paf1/RNA Polymerase II Complex Component) is a Protein Coding gene. Diseases associated with CTR9 include Hereditary Wilms' Tumor. Among its related pathways are Metabolism of proteins and Gene Expression. Gene Ontology (GO) annotations related to this gene include SH2 domain binding and RNA polymerase II core binding.

CTR9 Homolog, Paf1/RNA Polymerase II Complex Component

Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity).

Blastocyst growth Source: Ensembl
Blastocyst hatching Source: Ensembl
Cellular response to lipopolysaccharide Source: UniProtKB
Endodermal cell fate commitment Source: UniProtKB
Histone H2B ubiquitination Source: UniProtKB
Histone H3-K4 trimethylation Source: UniProtKB
Histone monoubiquitination Source: UniProtKB
Inner cell mass cell differentiation Source: Ensembl
Interleukin-6-mediated signaling pathway Source: UniProtKB
Negative regulation of mRNA polyadenylation Source: UniProtKB
Negative regulation of myeloid cell differentiation Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of histone H2B ubiquitination Source: UniProtKB
Positive regulation of histone H3-K4 methylation Source: UniProtKB
Positive regulation of histone H3-K79 methylation Source: UniProtKB
Protein ubiquitination Source: Reactome
Receptor signaling pathway via JAK-STAT Source: UniProtKB
Regulation of genetic imprinting Source: Ensembl
Regulation of histone H3-K4 methylation Source: GO_Central
Regulation of transcription, DNA-templated Source: GO_Central
Stem cell population maintenance Source: UniProtKB
Transcription by RNA polymerase II Source: Reactome
Transcription elongation from RNA polymerase II promoter Source: GO_Central
Trophectodermal cell differentiation Source: Ensembl
Wnt signaling pathway Source: UniProtKB-KW

Nucleus speckle