DEFB1

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis.
Full Name
Defensin Beta 1
Function
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636).
Biological Process
Antibacterial humoral response Source: UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Antimicrobial humoral response Source: Reactome
Calcium-mediated signaling using intracellular calcium source Source: UniProtKB
cAMP-mediated signaling Source: UniProtKB
Chemotaxis Source: ProtInc
Defense response to bacterium Source: MGI
Defense response to Gram-negative bacterium Source: UniProtKB
Defense response to Gram-positive bacterium Source: UniProtKB
G protein-coupled receptor signaling pathway Source: ProtInc
Immune response Source: ProtInc
Innate immune response Source: UniProtKB
Innate immune response in mucosa Source: UniProtKB
Positive regulation of flagellated sperm motility involved in capacitation Source: UniProtKB
Response to bacterium Source: UniProtKB
Cellular Location
Secreted; Membrane. Associates with tumor cell membrane-derived microvesicles (PubMed:23938203).
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Anti-DEFB1 antibodies

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Recombinant Mouse Anti-Defensin, beta-2 (a.a. 4-41) Antibody (L12-4C-C2) (CBMAB-MD1332-LY)

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Target: DEFB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: L12-4C-C2
Application*: E
Datasheet SDS

Human DEFB1 ELISA Kit (V2LY-0626-LY5447)

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Target: DEFB1
Sensitivity: 0.00058 ng/mL
Detection Range: 0.001-0.4 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Cattle DEFB1 ELISA Kit (V2LY-0626-LY380)

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Target: DEFB1
Sensitivity: 0.54 ng/mL
Detection Range: 1-400 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Cattle
Assay Type: Sandwich
Reactivity: Cattle
Datasheet SDS

Mouse Defb1 ELISA Kit (2) (V2LY-0626-LY3225)

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Target: Defb1
Sensitivity: 0.0052 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Datasheet SDS

Human DEFB1 ELISA Kit (2) (V2LY-0626-LY2164)

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Target: DEFB1
Sensitivity: 0.0023 ng/mL
Detection Range: 0.005-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Defb1 ELISA Kit (V2LY-0626-LY1479)

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Target: Defb1
Sensitivity: 0.251 ng/mL
Detection Range: 0.5-100 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Datasheet SDS

Human Recombinant DEFB1 protein, hFc Tag (V2LY-0526-LY2334)

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Target: DEFB1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-68
Tag: hFc Tag
Datasheet SDS

Rabbit Anti-DEFB1 Recombinant Antibody (
1F5) (V2LY-0725-LY961)

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Target: DEFB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 1F5
Application*: E, F
Datasheet SDS

Rabbit Anti-DEFB1 Recombinant Antibody (MD1332) (V2LY-0425-LY161)

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Target: DEFB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: MD1332
Application*: WB
Datasheet SDS

Rabbit Anti-DEFB1 Recombinant Antibody (MD1331) (V2LY-0425-LY160)

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Target: DEFB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: MD1331
Application*: E, F
Datasheet SDS

Recombinant Mouse Anti-Defensin, beta-1 (a.a. 1-36) Antibody (11-14CB-D10) (CBMAB-MD1331-LY)

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Target: DEFB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11-14CB-D10
Application*: E, WB
Datasheet SDS

Mouse Anti-DEFB1 Recombinant Antibody (M4-14B-H4) (CBMAB-D0683-YC)

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Target: DEFB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: M4-14B-H4
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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