Human DEFB1 ELISA Kit (V2LY-0626-LY5447)

Name: Human DEFB1 ELISA Kit
SKU: V2LY-0626-LY5447
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.00058 ng/mL

Detection Range

0.001-0.4 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

7.4 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Defensin Beta 1

Function

Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636).

Biological Process

Antibacterial humoral response Source: UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Antimicrobial humoral response Source: Reactome
Calcium-mediated signaling using intracellular calcium source Source: UniProtKB
cAMP-mediated signaling Source: UniProtKB
Chemotaxis Source: ProtInc
Defense response to bacterium Source: MGI
Defense response to Gram-negative bacterium Source: UniProtKB
Defense response to Gram-positive bacterium Source: UniProtKB
G protein-coupled receptor signaling pathway Source: ProtInc
Immune response Source: ProtInc
Innate immune response Source: UniProtKB
Innate immune response in mucosa Source: UniProtKB
Positive regulation of flagellated sperm motility involved in capacitation Source: UniProtKB
Response to bacterium Source: UniProtKB

Cellular Location

Secreted; Membrane. Associates with tumor cell membrane-derived microvesicles (PubMed:23938203).

Li, S., Li, H., Xu, Y., Ning, W., Hu, S., Wei, S., ... & Liu, M. (2022). Implications of Human Antimicrobial Peptide Defensin Beta-1 in Clinical Oral Squamous Cell Carcinoma Patients via an Integrated Bioinformatics Approach. Computational and Mathematical Methods in Medicine, 2022.

Ślebioda, Z., Woźniak, T., Dorocka‐Bobkowska, B., Woźniewicz, M., & Kowalska, A. (2021). Beta‐defensin 1 gene polymorphisms in the pathologies of the oral cavity—Data from meta‐analysis: Association only with rs1047031 not with rs1800972, rs1799946, and rs11362. Journal of Oral Pathology & Medicine, 50(1), 22-31.

Singh, J. K. J., Vaithilingam, R. D., Ng, C. C., Baharuddin, N. A., Safii, S. H., & Rahman, M. T. (2021). Prostaglandin-endoperoxide synthase (PTGS2) and Defensin beta 1 (DEFB1) gene polymorphisms are not associated with periodontitis in Malays. The Malaysian journal of pathology, 43(3), 425-434.

Salem, R. M., Abdelrahman, A. M. N., Abd El‐Kareem, H. M., & Seif, M. (2021). DEFB1 gene polymorphisms modify vitiligo extent and response to NB‐UVB phototherapy. Dermatologic Therapy, 34(3), e14921.

Antunes, L. S., Carvalho, L., Petean, I. B. F., Antunes, L. A., Freitas, J. V., Salles, A. G., ... & Sousa‐Neto, M. D. (2021). Association between genetic polymorphisms in the promoter region of the defensin beta 1 gene and persistent apical periodontitis. International Endodontic Journal, 54(1), 38-45.

Hatipoğlu, Ö., & Saydam, F. (2020). Association between rs11362 polymorphism in the beta-defensin 1 (DEFB1) gene and dental caries: A meta-analysis. Journal of Oral Biosciences, 62(3), 272-279.

Subbiah, H. V., Babu, P. R., & Subbiah, U. (2020). In silico analysis of non-synonymous single nucleotide polymorphisms of human DEFB1 gene. Egyptian Journal of Medical Human Genetics, 21(1), 1-9.

Kallel, A., Salem, T. B., Hammami, M. B., Said, F., Jemaa, R., Houman, M. H., & Feki, M. (2019). Association of systemic beta-defensin-1 and-20G/A DEFB1 gene polymorphism with Behcet's disease. European journal of internal medicine, 65, 58-62.

Liu, D., Ray, B., Neavin, D. R., Zhang, J., Athreya, A. P., Biernacka, J. M., ... & Weinshilboum, R. M. (2018). Beta-defensin 1, aryl hydrocarbon receptor and plasma kynurenine in major depressive disorder: metabolomics-informed genomics. Translational psychiatry, 8(1), 1-13.

Lips, A., Antunes, L. S., Antunes, L. A., de Abreu, J. G. B., Barreiros, D., de Oliveira, D. S. B., ... & Küchler, E. C. (2017). Genetic polymorphisms in DEFB1 and miRNA202 are involved in salivary human β-defensin 1 levels and caries experience in children. Caries Research, 51(3), 209-215.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant DEFB1 protein, hFc Tag (CAT#: V2LY-0526-LY2334)

Mouse Defb1 ELISA Kit (CAT#: V2LY-0626-LY1479)

Human DEFB1 ELISA Kit (2) (CAT#: V2LY-0626-LY2164)

Mouse Defb1 ELISA Kit (2) (CAT#: V2LY-0626-LY3225)

Cattle DEFB1 ELISA Kit (CAT#: V2LY-0626-LY380)

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Mouse Defb1 ELISA Kit (2) (CAT#: V2LY-0626-LY3225)

Rabbit Anti-DEFB1 Recombinant Antibody (MD1331) (CAT#: V2LY-0425-LY160)

Rabbit Anti-DEFB1 Recombinant Antibody (MD1332) (CAT#: V2LY-0425-LY161)

Human Recombinant DEFB1 protein, hFc Tag (CAT#: V2LY-0526-LY2334)

Cattle DEFB1 ELISA Kit (CAT#: V2LY-0626-LY380)

Mouse Defb1 ELISA Kit (CAT#: V2LY-0626-LY1479)

Mouse Anti-DEFB1 Recombinant Antibody (M4-14B-H4) (CAT#: CBMAB-D0683-YC)

Recombinant Mouse Anti-Defensin, beta-1 (a.a. 1-36) Antibody (11-14CB-D10) (CAT#: CBMAB-MD1331-LY)

Rabbit Anti-DEFB1 Recombinant Antibody (
1F5) (CAT#: V2LY-0725-LY961)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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