DPH2

This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

DPH2 homolog (S. cerevisiae)

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).

Peptidyl-diphthamide biosynthetic process from peptidyl-histidine Source: GO_Central

Cytosol

Extracellular: 30-448
Helical: 449-469
Cytoplasmic: 470-517