EIF2S2

Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Full Name
Eukaryotic Translation Initiation Factor 2 Subunit Beta
Research Area
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
Biological Process
Formation of cytoplasmic translation initiation complex Source: GO_Central
Formation of translation preinitiation complex Source: GO_Central
In utero embryonic development Source: Ensembl
Male germ cell proliferation Source: Ensembl
Male gonad development Source: Ensembl
Cellular Location
Cytosol; Cytoplasm; Eukaryotic translation initiation factor 2 complex
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Anti-EIF2S2 antibodies

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Mouse Anti-EIF2S2 Recombinant Antibody (EG1065) (V2LY-0425-LY1683)

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Target: EIF2S2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: EG1065
Application*: WB, E, IF, P
Datasheet SDS

Mouse Anti-EIF2S2 Recombinant Antibody (CBFYE-0669) (V2LY-0425-LY1682)

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Target: EIF2S2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0669
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-EIF2S2 Recombinant Antibody (CBFYE-0668) (V2LY-0425-LY1681)

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Target: EIF2S2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0668
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-EIF2S2 Recombinant Antibody (CBFYE-0667) (V2LY-0425-LY1680)

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Target: EIF2S2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0667
Application*: E, IF, IP, WB
Datasheet SDS

Rabbit Anti-EIF2S2 Recombinant Antibody (EG1065) (CBMAB-EN1256-LY)

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Target: EIF2S2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1065
Application*: WB: 1:500~1:1000 ELISA: 1:5000
Datasheet SDS

Mouse Anti-EIF2S2 Recombinant Antibody (CBFYE-0669) (CBMAB-E1086-FY)

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Target: EIF2S2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Human
Clone: CBFYE-0669
Application*: WB, E
Datasheet SDS

Rabbit Anti-EIF2S2 Recombinant Antibody (CBFYE-0668) (CBMAB-E1085-FY)

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Target: EIF2S2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-0668
Application*: WB, IP, F, IF
Datasheet SDS

Mouse Anti-EIF2S2 (AA 1-100) Recombinant Antibody (CBFYE-0667) (CBMAB-E1084-FY)

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Target: EIF2S2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0667
Application*: E, IF, P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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