Mouse Anti-EIF2S2 Recombinant Antibody (CBFYE-0668) (V2LY-0425-LY1681)

Name: Mouse Anti-EIF2S2 Recombinant Antibody (CBFYE-0668)
SKU: V2LY-0425-LY1681
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYE-0668

Application

ELISA, IF, IP, WB

Immunogen

Amino acids 131-333 mapping at the C-terminus of human eIF2β.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
ELISA	1:100-1:1,000
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Gelatin & PBS

Preservative

Sodium Azide

Concentration

0.2 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Eukaryotic Translation Initiation Factor 2 Subunit Beta

Entrez Gene ID

Human	8894
Mouse	67204
Rat	296302

UniProt ID

Human	P20042
Mouse	Q99L45
Rat	Q6P685

Research Area

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Biological Process

Formation of cytoplasmic translation initiation complex Source: GO_Central
Formation of translation preinitiation complex Source: GO_Central
In utero embryonic development Source: Ensembl
Male germ cell proliferation Source: Ensembl
Male gonad development Source: Ensembl

Cellular Location

Cytosol; Cytoplasm; Eukaryotic translation initiation factor 2 complex

Yang, J. W., Yuan, L. L., Gao, Y., Liu, X. S., Wang, Y. J., Zhou, L. M., ... & Pei, Z. J. (2021). 18F-FDG PET/CT metabolic parameters correlate with EIF2S2 expression status in colorectal cancer. Journal of Cancer, 12(19), 5838.

Ji, P., Wang, H., Cheng, Y., & Liang, S. (2021). Prognostic prediction and gene regulation network of EIF2S2 in hepatocellular carcinoma based on data mining. Journal of Gastrointestinal Oncology, 12(6), 3061.

Zhang, J., Li, S., Zhang, L., Xu, J., Song, M., Shao, T., ... & Li, Y. (2020). RBP EIF2S2 promotes tumorigenesis and progression by regulating MYC-mediated inhibition via FHIT-related enhancers. Molecular Therapy, 28(4), 1105-1118.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rabbit Anti-EIF2S2 Recombinant Antibody (CBFYE-0668) (CAT#: CBMAB-E1085-FY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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